Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials

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Title: Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials
Authors: Mega, JL
Stitziel, NO
Smith, JG
Chasman, DI
Caulfield, MJ
Devlin, JJ
Nordio, F
Hyde, CL
Cannon, CP
Sacks, FM
Poulter, NR
Sever, PS
Ridker, PM
Braunwald, E
Melander, O
Kathiresan, S
Sabatine, MS
Item Type: Journal Article
Issue Date: 6-Jun-2015
URI: http://hdl.handle.net/10044/1/52525
DOI: https://dx.doi.org/10.1016/S0140-6736(14)61730-X
ISSN: 0140-6736
Publisher: ELSEVIER SCIENCE INC
Start Page: 2264
End Page: 2271
Journal / Book Title: LANCET
Volume: 385
Issue: 9984
Copyright Statement: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
National Institute for Health Research
National Institute for Health Research
Funder's Grant Number: NF-SI-0510-10055
RDC02 79560
n/a
NF-SI-0513-10059
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
RECURRENT MYOCARDIAL-INFARCTION
CARDIOVASCULAR-DISEASE
ARTERY-DISEASE
SUSCEPTIBILITY LOCI
RANDOMIZED-TRIALS
LDL CHOLESTEROL
CHROMOSOME 9P21
GRACE GENETICS
CARDIAC DEATH
POLYMORPHISMS
Coronary Disease
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Numbers Needed To Treat
Primary Prevention
Recurrence
Risk Assessment
Secondary Prevention
Treatment Outcome
Humans
Coronary Disease
Recurrence
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Treatment Outcome
Risk Assessment
Primary Prevention
Secondary Prevention
Numbers Needed To Treat
11 Medical And Health Sciences
General & Internal Medicine
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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