Effects of microchannel confinement on acoustic vaporisation of ultrasound phase change contrast agents

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Title: Effects of microchannel confinement on acoustic vaporisation of ultrasound phase change contrast agents
Author(s): Lin, S
Zhang, G
Leow, CH
Tang, M-X
Item Type: Journal Article
Abstract: The sub-micron phase change contrast agent (PCCA) composed of a perfluorocarbon liquid core can be activated into gaseous state and form stable echogenic microbubbles for contrast-enhanced ultrasound imaging. It has shown great promise in imaging microvasculature, tumour microenvironment, and cancer cells. Although PCCAs have been extensively studied for different diagnostic and therapeutic applications, the effect of biologically geometrical confinement on the acoustic vaporisation of PCCAs is still not clear. We have investigated the difference in PCCA-produced ultrasound contrast enhancement after acoustic activation with and without a microvessel confinement on a microchannel phantom. The experimental results indicated more than one-order of magnitude less acoustic vaporisation in a microchannel than that in a free environment taking into account the attenuation effect of the vessel on the microbubble scattering. This may provide an improved understanding in the applications of PCCAs in vivo.
Publication Date: 7-Aug-2017
Date of Acceptance: 18-Jul-2017
URI: http://hdl.handle.net/10044/1/52148
DOI: https://dx.doi.org/10.1088/1361-6560/aa8076
ISSN: 0031-9155
Publisher: IOP PUBLISHING LTD
Start Page: 6884
End Page: 6898
Journal / Book Title: PHYSICS IN MEDICINE AND BIOLOGY
Volume: 62
Issue: 17
Copyright Statement: © 2017 Institute of Physics and Engineering in Medicine. This is an author-created, un-copyedited version of an article accepted for publication in Physics in Medicine and Biology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at https://dx.doi.org/10.1088/1361-6560/aa8076
Keywords: Science & Technology
Technology
Life Sciences & Biomedicine
Engineering, Biomedical
Radiology, Nuclear Medicine & Medical Imaging
Engineering
ultrasound imaging
phase change contrast agent
acoustic vaporisation
microvascular
microbubble
image quantification
BLOOD-BRAIN-BARRIER
DROPLET VAPORIZATION
DRUG-DELIVERY
IN-VITRO
PERFLUOROCARBON DROPLETS
SHIFT DROPLETS
NANODROPLETS
ACTIVATION
THERAPY
CANCER
0299 Other Physical Sciences
0903 Biomedical Engineering
Nuclear Medicine & Medical Imaging
Publication Status: Published
Appears in Collections:Faculty of Engineering
Bioengineering



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