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Rapid contrast matching by microfluidic SANS

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Microflow SANS - Adamo et al.pdfAccepted version2.81 MBAdobe PDFView/Open
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Title: Rapid contrast matching by microfluidic SANS
Authors: Adamo, M
Poulos, AS
Miller, RM
Lopez, CG
Martel, A
Porcar, L
Cabral, JT
Item Type: Journal Article
Abstract: We report a microfluidic approach to perform small angle neutron scattering (SANS) measurements of contrast variation and matching, extensively employed in soft and biological matter research. We integrate a low scattering background microfluidic mixer and serpentine channel in a SANS beamline to yield a single phase, continuous flow, reconfigurable liquid cell. By contrast with conventional, sequential measurements of discrete (typically 4–6) solutions of varying isotopic solvent composition, our approach continually varies solution composition during SANS acquisition. We experimentally and computationally determine the effects of flow dispersion and neutron beam overillumination of microchannels in terms of the composition resolution and precision. The approach is demonstrated with model systems: H2O/D2O mixtures, a surfactant (sodium dodecyl sulfate, SDS), a triblock copolymer (pluronic F127), and silica nanoparticles (Ludox) in isotopic aqueous mixtures. The system is able to zoom into a composition window to refine contrast matching conditions, and robustly resolve solute structure and form factors by simultaneous fitting of scattering data with continuously varying contrast. We conclude by benchmarking our microflow-SANS with the discrete approach, in terms of volume required, composition resolution and (preparation and measurement) time required, proposing a leap forward in equilibrium, liquid solution phase mapping and contrast variation by SANS.
Issue Date: 28-Mar-2017
Date of Acceptance: 27-Mar-2017
URI: http://hdl.handle.net/10044/1/52111
DOI: https://dx.doi.org/10.1039/c7lc00179g
ISSN: 1473-0189
Publisher: Royal Society of Chemistry
Start Page: 1559
End Page: 1569
Journal / Book Title: Lab on a Chip
Volume: 17
Issue: 9
Copyright Statement: © The Royal Society of Chemistry 2017
Keywords: Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Chemistry, Multidisciplinary
Chemistry, Analytical
Nanoscience & Nanotechnology
Biochemistry & Molecular Biology
Chemistry
Science & Technology - Other Topics
X-RAY-SCATTERING
SAMPLE-PREPARATION PLATFORM
ANGLE NEUTRON-SCATTERING
FRONTAL PHOTOPOLYMERIZATION
FLOW
SURFACTANT
DIFFUSION
SAXS
CHIP
MICELLES
03 Chemical Sciences
09 Engineering
Analytical Chemistry
Publication Status: Published
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Chemical Engineering
Faculty of Natural Sciences



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