The potential of anti-infectives and immunomodulators as therapies for asthma and asthma exacerbations.

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Title: The potential of anti-infectives and immunomodulators as therapies for asthma and asthma exacerbations.
Author(s): Edwards, MR
Walton, RP
Jackson, DJ
Feleszko, W
Skevaki, C
Jartti, T
Makrinoti, H
Nikonova, A
Shilovskiy, IP
Schwarze, J
Johnston, SL
Khaitov, MR
EAACI Anti-infectives in Asthma and Asthma Exacerbations Task Force
Item Type: Journal Article
Abstract: Asthma is responsible for approximately 25,000 deaths annually in Europe despite available medicines that maintain asthma control and reduce asthma exacerbations. Better treatments are urgently needed for the control of chronic asthma and reduction in asthma exacerbations, the major cause of asthma mortality. Much research spanning >20 years shows a strong association between microorganisms including pathogens in asthma onset, severity and exacerbation, yet with the exception of antibiotics, few treatments are available that specifically target the offending pathogens. Recent insights into the microbiome suggest that modulating commensal organisms within the gut or lung may also be a possible way to treat/prevent asthma. The European Academy of Allergy & Clinical Immunology Task Force on Anti-infectives in Asthma was initiated to investigate the potential of anti-infectives and immunomodulators in asthma. This review provides a concise summary of the current literature and aimed to identify and address key questions that concern the use of anti-infectives and both microbe- and host-based immunomodulators and their feasibility for use in asthma.
Publication Date: 10-Aug-2017
Date of Acceptance: 16-Jul-2017
URI: http://hdl.handle.net/10044/1/52013
DOI: https://dx.doi.org/10.1111/all.13257
ISSN: 0105-4538
Publisher: Wiley
Start Page: 50
End Page: 63
Journal / Book Title: Allergy
Volume: 73
Issue: 1
Copyright Statement: This is the peer reviewed version of the following article: Edwards MR, Walton RP, Jackson DJ, et al., EAACI Anti-infectives in Asthma and Asthma Exacerbations Task Force. The potential of anti-infectives and immunomodulators as therapies for asthma and asthma exacerbations. Allergy. 2017;00:1–14, which has been published in final form at https://dx.doi.org/10.1111/all.13257. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Keywords: Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
anti-infective
Asthma
immunomodulator
infection
lung
RESPIRATORY SYNCYTIAL VIRUS
RANDOMIZED CLINICAL-TRIAL
PLACEBO-CONTROLLED TRIAL
ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS
ATTENUATED INFLUENZA VACCINE
BRONCHIAL EPITHELIAL-CELLS
VITAMIN-D
CHILDHOOD ASTHMA
DOUBLE-BLIND
PNEUMOCOCCAL VACCINATION
Asthma
anti-infective
immunomodulator
infection
lung
EAACI Anti-infectives in Asthma and Asthma Exacerbations Task Force
Asthma
anti-infective
immunomodulator
infection
lung
1107 Immunology
Allergy
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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