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Programming membrane permeability using integrated membrane pores and blockers as molecular regulators

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Title: Programming membrane permeability using integrated membrane pores and blockers as molecular regulators
Authors: Thomas, JM
Friddin, MS
Ces, O
Elani, Y
Item Type: Journal Article
Abstract: We report a bottom-up synthetic biology approach to engineering vesicles with programmable permeabilities. Exploiting the concentration-dependent relationship between constitutively active pores (alpha-hemolysin) and blockers allows blockers to behave as molecular regulators for tuning permeability, enabling us to systematically modulate cargo release kinetics without changing the lipid fabric of the system.
Issue Date: 1-Nov-2017
Date of Acceptance: 16-Oct-2017
URI: http://hdl.handle.net/10044/1/51915
DOI: https://dx.doi.org/10.1039/C7CC05423H
ISSN: 1359-7345
Publisher: Royal Society of Chemistry
Start Page: 12282
End Page: 12285
Journal / Book Title: Chemical Communications
Volume: 53
Copyright Statement: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/J017566/1
EP/N016998/1
Keywords: 03 Chemical Sciences
Organic Chemistry
Publication Status: Published
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Faculty of Natural Sciences



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