Remote control of glucose homeostasis in vivo using photopharmacology

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Title: Remote control of glucose homeostasis in vivo using photopharmacology
Authors: Mehta, ZB
Johnston, NR
Nguyen-Tu, M-S
Broichhagen, J
Schultz, P
Larner, DP
Leclerc, I
Trauner, D
Rutter, GA
Hodson, DJ
Item Type: Journal Article
Abstract: Photopharmacology describes the use of light to precisely deliver drug activity in space and time. Such approaches promise to improve drug specificity by reducing off-target effects. As a proof-of-concept, we have subjected the fourth generation photoswitchable sulfonylurea JB253 to comprehensive toxicology assessment, including mutagenicity and maximum/repeated tolerated dose studies, as well as in vivo testing in rodents. Here, we show that JB253 is well-tolerated with minimal mutagenicity and can be used to optically-control glucose homeostasis in anesthetized mice following delivery of blue light to the pancreas. These studies provide the first demonstration that photopharmacology may one day be applicable to the light-guided treatment of type 2 diabetes and other metabolic disease states in vivo in humans.
Issue Date: 22-Mar-2017
Date of Acceptance: 21-Feb-2017
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 7
Copyright Statement: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit © The Author(s) 2017
Sponsor/Funder: Diabetes UK
Funder's Grant Number: 15821
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Publication Status: Published
Article Number: 291
Appears in Collections:Department of Medicine
Faculty of Medicine

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