Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3).

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Title: Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3).
Author(s): Fanidi, A
Muller, DC
Yuan, J-M
Stevens, VL
Weinstein, SJ
Albanes, D
Prentice, R
Thomsen, CA
Pettinger, M
Cai, Q
Blot, WJ
Wu, J
Arslan, AA
Zeleniuch-Jacquotte, A
McCullough, ML
Le Marchand, L
Wilkens, LR
Haiman, CA
Zhang, X
Han, J
Stampfer, MJ
Smith-Warner, SA
Giovannucci, E
Giles, GG
Hodge, AM
Severi, G
Johansson, M
Grankvist, K
Langhammer, A
Krokstad, S
Næss, M
Wang, R
Gao, Y-T
Butler, LM
Koh, W-P
Shu, X-O
Xiang, Y-B
Li, H
Zheng, W
Lan, Q
Visvanathan, K
Bolton, JH
Ueland, PM
Midttun, Ø
Ulvik, A
Caporaso, NE
Purdue, M
Ziegler, RG
Freedman, ND
Buring, JE
Lee, I-M
Sesso, HD
Gaziano, JM
Manjer, J
Ericson, U
Relton, C
Brennan, P
Johansson, M
Item Type: Journal Article
Abstract: Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown. Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status. Centralized biochemical analyses were performed to measure circulating concentrations of vitamin B6, folate, and methionine, as well as cotinine as an indicator of recent tobacco exposure. The association between these biomarkers and lung cancer risk was evaluated using conditional logistic regression models. Results: Participants with higher circulating concentrations of vitamin B6 and folate had a modestly decreased risk of lung cancer risk overall, the odds ratios when comparing the top and bottom fourths (OR 4vs1 ) being 0.88 (95% confidence interval [CI] = 0.78 to 1.00) and 0.86 (95% CI = 0.74 to 0.99), respectively. We found stronger associations among men (vitamin B6: OR 4vs1 = 0.74, 95% CI = 0.62 to 0.89; folate: OR 4vs1 = 0.75, 95% CI = 0.61 to 0.93) and ever smokers (vitamin B6: OR 4vs1 = 0.78, 95% CI = 0.67 to 0.91; folate: OR 4vs1 = 0.87, 95% CI = 0.73 to 1.03). We further noted that the association of folate was restricted to Europe/Australia and Asia, whereas no clear association was observed for the United States. Circulating concentrations of methionine were not associated with lung cancer risk overall or in important subgroups. Conclusions: Although confounding by tobacco exposure or reverse causation cannot be ruled out, these study results are compatible with a small decrease in lung cancer risk in ever smokers who avoid low concentrations of circulating folate and vitamin B6.
Publication Date: 22-Jul-2017
Date of Acceptance: 12-May-2017
URI: http://hdl.handle.net/10044/1/51839
DOI: https://dx.doi.org/10.1093/jnci/djx119
ISSN: 1460-2105
Publisher: Oxford University Press (OUP)
Journal / Book Title: JNCI: Journal of the National Cancer Institute
Volume: 110
Issue: 1
Copyright Statement: This is a pre-copyedited, author-produced PDF of an article accepted for publication in JNCI: Journal of the National Cancer Institute following peer review. The version of record Anouar Fanidi, David C. Muller, Jian-Min Yuan, Victoria L. Stevens, Stephanie J. Weinstein, Demetrius Albanes, Ross Prentice, Cynthia A. Thomsen, Mary Pettinger, Qiuyin Cai, William J. Blot, Jie Wu, Alan A. Arslan, Anne Zeleniuch-Jacquotte, Marjorie L. McCullough, Loic Le Marchand, Lynne R. Wilkens, Christopher A. Haiman, Xuehong Zhang, Jiali Han, Meir J. Stampfer, Stephanie A. Smith-Warner, Edward Giovannucci, Graham G. Giles, Allison M. Hodge, Gianluca Severi, Mikael Johansson, Kjell Grankvist, Arnulf Langhammer, Steinar Krokstad, Marit Næss, Renwei Wang, Yu-Tang Gao, Lesley M. Butler, Woon-Puay Koh, Xiao-Ou Shu, Yong-Bing Xiang, Honglan Li, Wei Zheng, Qing Lan, Kala Visvanathan, Judith Hoffman Bolton, Per Magne Ueland, Øivind Midttun, Arve Ulvik, Neil E. Caporaso, Mark Purdue, Regina G. Ziegler, Neal D. Freedman, Julie E. Buring, I-Min Lee, Howard D. Sesso, J. Michael Gaziano, Jonas Manjer, Ulrika Ericson, Caroline Relton, Paul Brennan, Mattias Johansson; Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3), JNCI: Journal of the National Cancer Institute, Volume 110, Issue 1, 1 January 2018, djx119, https://doi.org/10.1093/jnci/djx119 is available online at: https://doi.org/10.1093/jnci/djx119
Keywords: Adult
Aged
Aged, 80 and over
Asia
Australia
Case-Control Studies
Cotinine
Europe
Female
Folic Acid
Humans
Incidence
Lung Neoplasms
Male
Methionine
Middle Aged
Prospective Studies
Protective Factors
Risk Factors
Sex Factors
Smoking
United States
Vitamin B 6
Humans
Lung Neoplasms
Cotinine
Folic Acid
Vitamin B 6
Methionine
Incidence
Risk Factors
Case-Control Studies
Prospective Studies
Smoking
Sex Factors
Adult
Aged
Aged, 80 and over
Middle Aged
United States
Asia
Australia
Europe
Female
Male
Protective Factors
Adult
Aged
Aged, 80 and over
Asia
Australia
Case-Control Studies
Cotinine
Europe
Female
Folic Acid
Humans
Incidence
Lung Neoplasms
Male
Methionine
Middle Aged
Prospective Studies
Protective Factors
Risk Factors
Sex Factors
Smoking
United States
Vitamin B 6
1112 Oncology And Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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