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Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis

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Title: Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis
Authors: Jamaati, H
Mortaz, E
Pajouhi, Z
Folkerts, G
Movassaghi, M
Moloudizargari, M
Adcock, IM
Garssen, J
Item Type: Journal Article
Abstract: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is globally known as one of the most important human pathogens. Mtb is estimated to infect nearly one third of the world's population with many subjects having a latent infection. Thus, from an estimated 2 billion people infected with Mtb, less than 10% may develop symptomatic TB. This indicates that the host immune system may constrain pathogen replication in most infected individuals. On entering the lungs of the host, Mtb initially encounters resident alveolar macrophages which can engulf and subsequently eliminate intracellular microbes via a plethora of bactericidal mechanisms including the generation of free radicals such as reactive oxygen and nitrogen species. Nitric oxide (NO), a key anti-mycobacterial molecule, is detected in the exhaled breath of patients infected with Mtb. Recent knowledge regarding the regulatory role of NO in airway function and Mtb proliferation paves the way of exploiting the beneficial effects of this molecule for the treatment of airway diseases. Here, we discuss the importance of NO in the pathogenesis of TB, the diagnostic use of exhaled and urinary NO in Mtb infection and the potential of NO-based treatments.
Issue Date: 12-Oct-2017
Date of Acceptance: 29-Sep-2017
URI: http://hdl.handle.net/10044/1/51794
DOI: https://dx.doi.org/10.3389/fmicb.2017.02008
ISSN: 1664-302X
Publisher: Frontiers
Journal / Book Title: Frontiers in Microbiology
Volume: 8
Copyright Statement: Copyright © 2017 Jamaati, Mortaz, Pajouhi, Folkerts, Movassaghi, Moloudizargari, Adcock and Garssen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 093080/Z/10/Z
Publication Status: Published
Article Number: 2008
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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