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Functionalisation of Carbon-Fluorine Bonds with Main Group Reagents

Title: Functionalisation of Carbon-Fluorine Bonds with Main Group Reagents
Authors: Chen, W
Bakewell, C
Crimmin, MR
Item Type: Journal Article
Abstract: Synthetic approaches to produce reactive chemical building blocks from fluorinated molecules by the functionalization of carbon–fluorine bonds with main group reagents are reviewed. The reaction types can be categorized as: (i) the formal 1,2-addition of C–F bonds across Si–Si, B–B, or Mg–Mg bonds; (ii) the oxidative addition of C–F bonds to Si(II), Ge(II), and Al(I) centres; and (iii) the dehydrogenative coupling of C–F bonds with Al–H or B–H bonds. Many of the advances have emerged between 2015–2016 and are largely focused upon aromatic substrates that contain sp2 C–F bonds.
Issue Date: 8-Dec-2016
Date of Acceptance: 8-Dec-2016
URI: http://hdl.handle.net/10044/1/51783
DOI: https://dx.doi.org/10.1055/s-0036-1588663
ISSN: 0039-7881
Publisher: Thieme Publishing
Start Page: 810
End Page: 821
Journal / Book Title: SYNTHESIS
Volume: 49
Issue: 4
Copyright Statement: © Georg Thieme Verlag Stuttgart · New York
Sponsor/Funder: The Royal Society
Commission of the European Communities
Commission of the European Communities
Funder's Grant Number: UF090149
655474
677367
Keywords: Science & Technology
Physical Sciences
Chemistry, Organic
Chemistry
fluorine
carbon-fluorine
functionalisation
borylation
silylation
alumination
magnesiation
C-F BOND
NUCLEOPHILIC AROMATIC-SUBSTITUTION
TRANSITION-METAL-COMPLEXES
RHODIUM BORYL COMPLEXES
OXIDATIVE ADDITION
CATALYTIC HYDRODEFLUORINATION
BUILDING-BLOCKS
USEFUL TOOL
H BONDS
ACTIVATION
0305 Organic Chemistry
Organic Chemistry
Publication Status: Published
Appears in Collections:Chemistry
Faculty of Natural Sciences



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