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Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Encapsulating Bioactive Hydrogels Improve Rat Heart Function Post Myocardial Infarction.

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Title: Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Encapsulating Bioactive Hydrogels Improve Rat Heart Function Post Myocardial Infarction.
Authors: Chow, A
Stuckey, DJ
Kidher, E
Rocco, M
Jabbour, RJ
Mansfield, CA
Darzi, A
Harding, SE
Stevens, MM
Athanasiou, T
Item Type: Journal Article
Abstract: Tissue engineering offers an exciting possibility for cardiac repair post myocardial infarction. We assessed the effects of combined polyethylene glycol hydrogel (PEG), human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM), and erythropoietin (EPO) therapy in a rat model of myocardial infarction. PEG with/out iPSC-CMs and EPO; iPSC-CMs in saline; or saline alone was injected into infarcted hearts shortly after infarction. Injection of almost any combination of the therapeutics limited acute elevations in chamber volumes. After 10¬†weeks, attenuation of ventricular remodeling was identified in all groups that received PEG injections, while ejection fractions were significantly increased in the gel-EPO, cell, and gel-cell-EPO groups. In all treatment groups, infarct thickness was increased and regions of muscle were identified within the scar. However, no grafted cells were detected. Hence, iPSC-CM-encapsulating bioactive hydrogel therapy can improve cardiac function post myocardial infarction and increase infarct thickness and muscle content despite a lack of sustained donor-cell engraftment.
Issue Date: 5-Oct-2017
Date of Acceptance: 1-Sep-2017
URI: http://hdl.handle.net/10044/1/51767
DOI: https://dx.doi.org/10.1016/j.stemcr.2017.09.003
ISSN: 2213-6711
Publisher: Elsevier (Cell Press)
Start Page: 1415
End Page: 1422
Journal / Book Title: Stem Cell Reports
Volume: 9
Issue: 5
Copyright Statement: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: British Heart Foundation
Wellcome Trust
British Heart Foundation
Funder's Grant Number: RM/13/1/30157
098411/Z/12/Z
RM/17/1/33377
Keywords: MRI
erythropoietin
hydrogel
iPSC-CMs
induced pluripotent stem cell-derived cardiomyocytes
myocardial infarction
myocardial tissue engineering
rat
Publication Status: Published online
Appears in Collections:Faculty of Engineering
Materials
Division of Surgery
National Heart and Lung Institute
Faculty of Medicine
Faculty of Natural Sciences



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