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Role of SMAD proteins in colitis-associated cancer: from known to the unknown.

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Title: Role of SMAD proteins in colitis-associated cancer: from known to the unknown.
Authors: Chandrasinghe, P
Cereser, B
Moorghen, M
Al Bakir, I
Tabassum, N
Hart, A
Stebbing, J
Warusavitarne, J
Item Type: Journal Article
Abstract: Small mothers against decapentaplegic (SMAD) proteins are a family of signal transduction molecules in transforming growth factor β (TGFβ) ligand pathways that have been found to have a key role in the pathogenesis of inflammatory bowel disease (IBD). Long standing IBD predisposes individuals to colitis-associated colorectal cancer (CAC), an entity that possess unique characteristics compared to hereditary and sporadic cancer. The ligands of the TGFβ super family along with SMADs have also been implicated in several aspects of colorectal cancer formation. SMAD proteins are shown to be involved in a number of potentially carcinogenic mechanisms such as altering gene transcription, controlling stem cell differentiation to causing epigenetic changes. Modulation of these proteins has emerged as a novel therapeutic intervention for IBD although its effect on carcinogenesis remains elusive. This account reviews available evidence linking SMAD proteins to CAC and explores the potential areas for future research in this area.Oncogene advance online publication, 4 September 2017; doi:10.1038/onc.2017.300.
Issue Date: 4-Sep-2017
Date of Acceptance: 19-Jul-2017
URI: http://hdl.handle.net/10044/1/51684
DOI: https://dx.doi.org/10.1038/onc.2017.300
ISSN: 0950-9232
Publisher: Nature Publishing Group
Start Page: 1
End Page: 7
Journal / Book Title: Oncogene
Volume: 37
Copyright Statement: Copyright © 2017, Rights Managed by Nature Publishing Group
Keywords: 1112 Oncology And Carcinogenesis
1103 Clinical Sciences
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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