A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011-2014

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Title: A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011-2014
Author(s): Rosner, BM
Schielke, A
Didelot, X
Kops, F
Breidenbach, J
Willrich, N
Goelz, G
Alter, T
Stingl, K
Josenhans, C
Suerbaum, S
Stark, K
Item Type: Journal Article
Abstract: Campylobacter infection is the most commonly notified bacterial enteritis in Germany. We performed a large combined case-control and source attribution study (Nov 2011-Feb 2014) to identify risk factors for sporadic intestinal Campylobacter infections and to determine the relative importance of various animal sources for human infections in Germany. We conducted multivariable logistic regression analysis to identify risk factors. Source attribution analysis was performed using the asymmetric island model based on MLST data of human and animal/food isolates. As animal sources we considered chicken, pig, pet dog or cat, cattle, and poultry other than chicken. Consumption of chicken meat and eating out were the most important risk factors for Campylobacter infections. Additional risk factors were preparation of poultry meat in the household; preparation of uncooked food and raw meat at the same time; contact with poultry animals; and the use of gastric acid inhibitors. The mean probability of human C. jejuni isolates to originate from chickens was highest (74%), whereas pigs were a negligible source for C. jejuni infections. Human C. coli isolates were likely to originate from chickens (56%) or from pigs (32%). Efforts need to be intensified along the food chain to reduce Campylobacter load, especially on chicken meat.
Publication Date: 11-Jul-2017
Date of Acceptance: 25-May-2017
URI: http://hdl.handle.net/10044/1/51595
DOI: https://dx.doi.org/10.1038/s41598-017-05227-x
ISSN: 2045-2322
Publisher: NATURE PUBLISHING GROUP
Journal / Book Title: SCIENTIFIC REPORTS
Volume: 7
Copyright Statement: © 2017 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre- ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per- mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ .
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
PROTON PUMP INHIBITORS
RISK-FACTORS
SALMONELLA-ENTERITIDIS
TYPHIMURIUM INFECTIONS
YOUNG-CHILDREN
NEW-ZEALAND
JEJUNI
GASTROENTERITIS
EPIDEMIOLOGY
NETHERLANDS
Publication Status: Published
Article Number: ARTN 5139
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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