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Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation.

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Title: Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation.
Authors: Brzosko, Z
Zannone, S
Schultz, W
Clopath, C
Paulsen, O
Item Type: Journal Article
Abstract: Spike timing-dependent plasticity (STDP) is under neuromodulatory control, which is correlated with distinct behavioral states. Previously we reported that dopamine, a reward signal, broadens the time window for synaptic potentiation and modulates the outcome of hippocampal STDP even when applied after the plasticity induction protocol (Brzosko et al., 2015). Here we demonstrate that sequential neuromodulation of STDP by acetylcholine and dopamine offers an efficacious model of reward-based navigation. Specifically, our experimental data in mouse hippocampal slices show that acetylcholine biases STDP towards synaptic depression, whilst subsequent application of dopamine converts this depression into potentiation. Incorporating this bidirectional neuromodulation-enabled correlational synaptic learning rule into a computational model yields effective navigation towards changing reward locations, as in natural foraging behavior. Thus, temporally sequenced neuromodulation of STDP enables associations to be made between actions and outcomes and also provides a possible mechanism for aligning the time scales of cellular and behavioral learning.
Issue Date: 10-Jul-2017
Date of Acceptance: 7-Jul-2017
URI: http://hdl.handle.net/10044/1/51594
DOI: https://dx.doi.org/10.7554/eLife.27756
ISSN: 2050-084X
Publisher: eLife Sciences Publications Ltd
Journal / Book Title: eLife
Volume: 6
Copyright Statement: © 2017 Brzosko et al. This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
Sponsor/Funder: Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Funder's Grant Number: 200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Keywords: Science & Technology
Life Sciences & Biomedicine
Biology
Life Sciences & Biomedicine - Other Topics
LONG-TERM POTENTIATION
DEPENDENT SYNAPTIC PLASTICITY
MUSCARINIC ACETYLCHOLINE-RECEPTORS
HIPPOCAMPAL CA1 NETWORK
RAT HIPPOCAMPUS
MOUSE HIPPOCAMPUS
LEARNING RULE
IN-VITRO
MODULATION
DEPRESSION
hippocampus
mouse
navigation
neuromodulation
neuroscience
reward
synaptic plasticity
Publication Status: Published
Conference Place: England
Article Number: e27756
Appears in Collections:Faculty of Engineering
Bioengineering



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