Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations

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Title: Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
Authors: Van Duijnhoven, FJB
Jenab, M
Hveem, K
Siersema, PD
Fedirko, V
Duell, EJ
Kampman, E
Halfweeg, A
Van Kranen, HJ
Van den Ouweland, JMW
Weiderpass, E
Murphy, N
Langhammer, A
Ness-Jensen, E
Olsen, A
Tjonneland, A
Overvad, K
Cadeau, C
Kvaskoff, M
Boutron-Ruault, M-C
Katzke, VA
Kuhn, T
Boeing, H
Trichopoulou, A
Kotanidou, A
Kritikou, M
Palli, D
Agnoli, C
Tumino, R
Panico, S
Matullo, G
Peeters, P
Brustad, M
Standahl Olsen, K
Lasheras, C
Obon-Santacana, M
Sanchez, M-J
Dorronsoro, M
Chirlaque, M-D
Barricarte, A
Manjer, J
Almquist, M
Renstrom, F
Ye, W
Wareham, N
Khaw, K-T
Bradbury, KE
Freisling, H
Aune, D
Norat, T
Riboli, E
Bueno-de-Mesquita, H
Item Type: Journal Article
Abstract: Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42–1.20); 0.94 (0.72–1.22); 1.12 (0.82–1.53) and 1.26 (0.79–2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
Issue Date: 22-Nov-2017
Date of Acceptance: 28-Sep-2017
ISSN: 0020-7136
Publisher: Wiley
Start Page: 1189
End Page: 1201
Journal / Book Title: International Journal of Cancer
Volume: 142
Copyright Statement: © 2017 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: SP23-CT-2005-006438
Keywords: cancer epidemiology
nested case-control study
pancreatic cancer
vitamin D
1112 Oncology And Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care

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