Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulations.

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Title: Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulations.
Authors: Villette, CC
Phillips, ATM
Item Type: Journal Article
Abstract: Bone functional tissue adaptation is a multiaspect physiological process driven by interrelated mechanical and biological stimuli which requires the combined activity of osteoclasts and osteoblasts. In previous work, the authors developed a phenomenological mesoscale structural modelling approach capable of predicting internal structure of the femur based on daily activity loading, which relied on the iterative update of the cross-sectional areas of truss and shell elements representative of trabecular and cortical bones, respectively. The objective of this study was to introduce trabecular reorientation in the phenomenological model at limited computational cost. To this aim, a metamodel derived from poroelastic microscale continuum simulations was used to predict the functional adaptation of a simplified proximal structural femur model. Clear smooth trabecular tracts are predicted to form in the regions corresponding to the main trabecular groups identified in literature, at minimal computational cost.
Issue Date: 9-Aug-2017
Date of Acceptance: 11-Jul-2017
URI: http://hdl.handle.net/10044/1/51248
DOI: https://dx.doi.org/10.1007/s10237-017-0939-x
ISSN: 1617-7940
Publisher: Springer Verlag
Start Page: 2077
End Page: 2091
Journal / Book Title: Biomechanics and Modeling in Mechanobiology
Volume: 16
Issue: 6
Copyright Statement: © The Author(s) 2017 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Bone remodelling
Mesoscale
Metamodel
Microscale
Poroelastic
Structural
Bone remodelling
Mesoscale
Metamodel
Microscale
Poroelastic
Structural
0913 Mechanical Engineering
0903 Biomedical Engineering
Biomedical Engineering
Publication Status: Published online
Appears in Collections:Faculty of Engineering
Civil and Environmental Engineering



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