The effect of body weight on distal airway function and airway inflammation

Title: The effect of body weight on distal airway function and airway inflammation
Authors: Van de Kant, KDG
Paredi, P
Meah, S
Kalsi, HS
Barnes, PJ
Usmani, OS
Item Type: Journal Article
Abstract: Background/Objectives: Obesity is a global health problem that adversely influences the respiratory system. We assessed the effects of body mass index (BMI) on distal airway function and airway inflammation. Subjects/Methods: Impulse oscillometry (IOS) as a measure of distal airway function, together with spirometry, were assessed in adults with a range of different BMIs. Airway inflammation was assessed with the fraction of exhaled nitric oxide (FeNO) and participants exhaled at various exhalation flows to determine alveolar and bronchial NO. Results: In total 34 subjects were enrolled in the study; 19 subjects had a normal BMI (18.50–24.99), whilst 15 subjects were overweight (BMI 25.00–29.99), or obese (BMI ≥30). All subjects had normal spirometry. However, IOS measures of airway resistance (R) at 5 Hz, 20 Hz and frequency dependence (R5–20) were elevated in overweight/obese individuals, compared to subjects with a normal BMI (median (interquartile range)); 5 Hz: 0.41 (0.37, 0.45) vs. 0.32 (0.30, 0.37) kPa/l/s; 20 Hz: 0.34 (0.30, 0.37) vs. 0.30 (0.26, 0.33) kPa/l/s; R5–20: 0.06 (0.04, 0.11) vs. 0.03 (0.01, 0.05) kPa/l/s; p < 0.05), whereas airway reactance at 20 Hz was decreased in overweight/obese individuals (20 Hz: 0.07 (0.03, 0.09) vs. 0.10 (0.07, 0.13) kPa/l/s, p = 0.009; 5 Hz: −0.12 (−0.15, −0.10) vs. −0.10 (−0.13, −0.09) kPa/l/s, p = 0.07). In contrast, within-breath IOS measures (a sign of expiratory flow limitation) and FeNO inflammatory measures, did not differ between groups (p > 0.05). Conclusions: Being overweight has significant effects on distal and central airway function as determined by IOS, which is not detected by spirometry. Obesity does not influence airway inflammation as measured by FeNO. IOS is a reliable technique to identify airway abnormalities in the presence of normal spirometry in overweight people.
Issue Date: 24-Nov-2015
Date of Acceptance: 5-Oct-2015
URI: http://hdl.handle.net/10044/1/50841
DOI: https://dx.doi.org/10.1016/j.orcp.2015.10.005
ISSN: 1871-403X
Publisher: Elsevier
Start Page: 564
End Page: 573
Journal / Book Title: Obesity Research and Clinical Practice
Volume: 10
Issue: 5
Copyright Statement: © 2015 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
Sponsor/Funder: National Institute for Health Research
Funder's Grant Number: CDF-2011-04-053
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Nutrition & Dietetics
Body mass index
Fraction of exhaled
nitric oxide
Impulse oscillometry
Lung function
EXHALED NITRIC-OXIDE
OBSTRUCTIVE PULMONARY-DISEASE
FORCED OSCILLATION TECHNIQUE
MASS INDEX
BARIATRIC SURGERY
OBESE SUBJECTS
RESPIRATORY RESISTANCE
INCIDENT ASTHMA
LUNG-VOLUMES
CHILDREN
Fraction of exhaled nitric oxide
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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