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Asthma and gender: the female lung

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Title: Asthma and gender: the female lung
Authors: Pignataro, FS
Bonini, M
Forgione, A
Melandri, S
Usmani, OS
Item Type: Journal Article
Abstract: Asthma is a common chronic disease that affects over 300 million people worldwide, resulting in a considerable socio-economic burden. Literature data suggest that asthma has a higher incidence in females, particularly at certain stages of pubertal development. Moreover, women seem to experience more asthma symptoms than men and to use more rescue medications, resulting in a reduced quality of life. Although several mechanisms have been proposed to explain these differences, there are not yet final data available in the literature on the role of gender in the pathogenesis of asthma and different behavior in females. Some study suggested a more prevalent hyper-responsiveness in women than in men. Nevertheless, in the literature definitive data on a possible different response to drugs used for asthma between males and females are not described. Understanding the mechanisms that underlie these gender differences in clinical history of asthma patients could give inspiration to new areas of research to obtain a more specific diagnostic and therapeutic approach gender-oriented.
Issue Date: 24-Feb-2017
Date of Acceptance: 19-Feb-2017
URI: http://hdl.handle.net/10044/1/50836
DOI: https://dx.doi.org/10.1016/j.phrs.2017.02.017
ISSN: 1043-6618
Publisher: Elsevier
Start Page: 384
End Page: 390
Journal / Book Title: Pharmacological Research
Volume: 119
Copyright Statement: © 2017 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Asthma
Gender
Bronchial responsiveness
Methacoline
RANDOMIZED CONTROLLED TRIAL
PERSISTENT ASTHMA
INHALED CORTICOSTEROIDS
EMERGENCY-DEPARTMENT
MENSTRUAL-CYCLE
SEX-DIFFERENCES
BRONCHIAL RESPONSIVENESS
PREMENSTRUAL ASTHMA
ONSET ASTHMA
AGE
Anti-Asthmatic Agents
Female
Humans
Lung
Male
Quality of Life
Sex Characteristics
Sex Factors
Treatment Outcome
1115 Pharmacology And Pharmaceutical Sciences
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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