Multisite assessment of aging-related Tau astrogliopathy (ARTAG)

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Title: Multisite assessment of aging-related Tau astrogliopathy (ARTAG)
Author(s): Kovacs, GG
Xie, SX
Lee, EB
Robinson, JL
Caswell, C
Irwin, DJ
Toledo, JB
Johnson, VE
Smith, DH
Alafuzoff, I
Attems, J
Bencze, J
Bieniek, KF
Bigio, EH
Bodi, I
Budka, H
Dickson, DW
Dugger, BN
Duyckaerts, C
Ferrer, I
Forrest, SL
Gelpi, E
Gentleman, SM
Giaccone, G
Grinberg, LT
Halliday, GM
Hatanpaa, KJ
Hof, PR
Hofer, M
Hortobagyi, T
Ironside, JW
King, A
Kofler, J
Kovari, E
Kril, JJ
Love, S
Mackenzie, IR
Mao, Q
Matej, R
McLean, C
Munoz, DG
Murray, ME
Neltner, J
Nelson, PT
Ritchie, D
Rodriguez, RD
Rohan, Z
Rozemuller, A
Sakai, K
Schultz, C
Seilhean, D
Smith, V
Tacik, P
Takahashi, H
Takao, M
Thal, DR
Weis, S
Wharton, SB
White, CL
Woulfe, JM
Yamada, M
Trojanowski, JQ
Item Type: Journal Article
Abstract: Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was >60% with a kappa value of 0.55 (95% CI 0.433–0.645). Moderate agreement (>90%, kappa 0.48, 95% CI 0.457–0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37–0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341–0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534–0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.
Publication Date: 7-Jun-2017
Date of Acceptance: 1-Jun-2017
URI: http://hdl.handle.net/10044/1/50654
DOI: https://dx.doi.org/10.1093/jnen/nlx041
ISSN: 1554-6578
Publisher: Oxford University Press (OUP)
Start Page: 605
End Page: 619
Journal / Book Title: Journal of Neuropathology and Experimental Neurology
Volume: 76
Issue: 7
Copyright Statement: © 2017 American Association of Neuropathologists, Inc. All rights reserved. This is a pre-copy-editing, author-produced version of an article accepted for publication in Journal of Neuropathology and Experimental Neurology following peer review. The definitive publisher-authenticated version is available online at: https://academic.oup.com/jnen/article-lookup/doi/10.1093/jnen/nlx041
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Pathology
Neurosciences & Neurology
Aging
ARTAG
Digital pathology
Interrater agreement
Neuropathology
Tau
Tau-astrogliopathy
BRAINNET EUROPE CONSORTIUM
PROGRESSIVE SUPRANUCLEAR PALSY
ARGYROPHILIC GRAIN DISEASE
ALZHEIMERS-DISEASE
NEUROFIBRILLARY PATHOLOGY
NEUROPATHOLOGIC CRITERIA
ASTROCYTES
AGREEMENT
DEGENERATION
GUIDELINES
ARTAG
Aging
Digital pathology
Interrater agreement
Neuropathology
Tau
Tau-astrogliopathy
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Pathology
Neurosciences & Neurology
Aging
ARTAG
Digital pathology
Interrater agreement
Neuropathology
Tau
Tau-astrogliopathy
BRAINNET EUROPE CONSORTIUM
PROGRESSIVE SUPRANUCLEAR PALSY
ARGYROPHILIC GRAIN DISEASE
ALZHEIMERS-DISEASE
NEUROFIBRILLARY PATHOLOGY
NEUROPATHOLOGIC CRITERIA
ASTROCYTES
AGREEMENT
DEGENERATION
GUIDELINES
1103 Clinical Sciences
1109 Neurosciences
Neurology & Neurosurgery
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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