Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast.

Title: Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast.
Authors: Caballero, OL
Shousha, S
Zhao, Q
Simpson, AJG
Coombes, RC
Neville, AM
Item Type: Journal Article
Abstract: Cancer/testis (CT) genes represent a unique class of genes, which are expressed by germ cells, normally silenced in somatic cells, but activated in various cancers. CT proteins can elicit spontaneous immune responses in cancer patients and this feature makes them attractive targets for immunotherapy-based approaches. We have previously reported that CTs are relatively commonly expressed in estrogen receptor (ER) negative, high risk carcinomas. In this study, we examined the expression of selected CT genes in ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and benign proliferative lesions of the breast. ER negative DCIS were found to be associated with significant CT gene expression together with HER2 positivity and a marked stromal immune response.
Issue Date: 1-Jan-2014
Date of Acceptance: 10-Dec-2013
URI: http://hdl.handle.net/10044/1/50636
ISSN: 2331-4737
Start Page: 14
End Page: 20
Journal / Book Title: Oncoscience
Volume: 1
Issue: 1
Copyright Statement: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: DCIS
ER negative
cancer/testis genes
Publication Status: Published online
Conference Place: United States
Appears in Collections:Division of Surgery
Division of Cancer
Department of Medicine
Faculty of Medicine



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