Immunoglobulin Free Light Chains in the Pathogenesis of Lung Disorders.

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Title: Immunoglobulin Free Light Chains in the Pathogenesis of Lung Disorders.
Authors: Mortaz, E
Adcock, IM
Jamaati, H
Khosravi, A
Movassaghi, M
Garssen, J
Alavi Mogadam, M
Redegeld, FA
Item Type: Journal Article
Abstract: Inflammation is an important component of numerous cancers and chronic diseases and many inflammatory mediators have been shown to have potential prognostic roles. Tumor-infiltrating mast cells can promote tumor growth and angiogenesis, but the mechanism of mast cell activation is unclear. Early studies have shown that immunoglobulin free light chains (FLC) can trigger mast cell activation in an antigen-specific manner. Increased expression of FLC is observed within the stroma of many human cancers including those of breast, colon, lung, pancreas, kidney, and skin. These overexpressed FLCs are co-localized to areas of mast cell infiltration. Importantly, FLC expression is associated with basal-like cancers with an aggressive phenotype. Moreover, FLC is expressed in areas of inflammatory cell infiltration and its expression is significantly associated with poor clinical outcome. In addition, serum and bronchoalveolar fluid FLC concentrations are increased in patients with idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP) compared to control subjects. In this review, we provide an update on the role of FLC in the pathogenesis of several lung disorders and indicate how this may contribute to new therapeutic opportunities.
Issue Date: 12-Aug-2017
Date of Acceptance: 27-Mar-2017
ISSN: 1735-1502
Publisher: Tehran University of Medical Sciences
Start Page: 282
End Page: 288
Journal / Book Title: Iranian Journal Of Allergy, Asthma and Immunology
Volume: 16
Issue: 4
Copyright Statement: This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 093080/Z/10/Z
Keywords: Asthma
Chronic obstructive lungs disease (COPD)
Free light chain
Hypersensitivity pneumonitis (HP)
Idiopathic pulmonary fibrosis (IPF)
Lung cancer
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine

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