Application of metabolic profiling to abdominal aortic aneurysm research

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Title: Application of metabolic profiling to abdominal aortic aneurysm research
Author(s): Qureshi, MI
Greco, M
Vorkas, PA
Holmest, E
Davies, AH
Item Type: Journal Article
Abstract: Abdominal aortic aneurysm (AAA) is a complex disease posing diagnostic and therapeutic challenges. Metabonomics may aid in the diagnosis of AAA, determination of individualized risk, discovery of therapeutic targets, and improve understanding of pathogenesis. A systematic review of the diversity and outcomes of existing AAA metabonomic research has been performed. Original research studies applying metabonomics to human aneurysmal disease are included. Seven relevant articles were identified: four studies were based on plasma/serum metabolite profiling, and three studies examined aneurysmal tissue. Aminomalonic acid, guanidinosuccinic acid, and glycerol emerge as potential plasma biomarkers of large aneurysm. Lipid profiling improves predictive models of aneurysm presence. Patterns of metabolite variation associated with AAA relate to carbohydrate and lipid metabolism. Perioperative perturbations in metabolites suggest differential systemic inflammatory responses to surgery, generating hypotheses for adjunctive perioperative therapy. Significant limitations include small study sizes, lack of correction for multiple testing false discovery rates, and single time-point sampling. Metabolic profiling carries the potential to identify biomarkers of AAA and elucidate pathways underlying aneurysmal disease. Statistically and methodologically robust studies are required for validation, addressing the hiatus in understanding mechanisms of aneurysm growth and developing effective treatment strategies.
Publication Date: 13-Mar-2017
Date of Acceptance: 12-Oct-2016
URI: http://hdl.handle.net/10044/1/50509
DOI: https://dx.doi.org/10.1021/acs.jproteome.6b00894
ISSN: 1535-3893
Publisher: American Chemical Society
Start Page: 2325
End Page: 2332
Journal / Book Title: Journal of Proteome Research
Volume: 16
Issue: 7
Copyright Statement: © 2017 American Chemical Society
Sponsor/Funder: The Circulation Foundation
Rosetrees Trust
Royal College Of Surgeons Of England
Funder's Grant Number: N/A
A573
N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemical Research Methods
Biochemistry & Molecular Biology
aneurysm
metabonomics
metabolomics
metabolic profiling
systems biology
arterial disease
NITRIC-OXIDE SYNTHASE
CARDIOVASCULAR-DISEASE
AMINOMALONIC ACID
MASS-SPECTROMETRY
SYSTEMS BIOLOGY
ATHEROSCLEROSIS
METABONOMICS
STATINS
INFLAMMATION
ASSOCIATION
aneurysm
arterial disease
metabolic profiling
metabolomics
metabonomics
systems biology
Science & Technology
Life Sciences & Biomedicine
Biochemical Research Methods
Biochemistry & Molecular Biology
aneurysm
metabonomics
metabolomics
metabolic profiling
systems biology
arterial disease
NITRIC-OXIDE SYNTHASE
CARDIOVASCULAR-DISEASE
AMINOMALONIC ACID
MASS-SPECTROMETRY
SYSTEMS BIOLOGY
ATHEROSCLEROSIS
METABONOMICS
STATINS
INFLAMMATION
ASSOCIATION
06 Biological Sciences
03 Chemical Sciences
Biochemistry & Molecular Biology
Publication Status: Published
Embargo Date: 2018-03-13
Appears in Collections:Division of Surgery
Faculty of Medicine



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