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Structure and functions of blood vessels and vascular niches in bone

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Title: Structure and functions of blood vessels and vascular niches in bone
Authors: Ramasamy, SK
Item Type: Journal Article
Abstract: Bone provides nurturing microenvironments for an array of cell types that coordinate important physiological functions of the skeleton, such as energy metabolism, mineral homeostasis, osteogenesis, and haematopoiesis. Endothelial cells form an intricate network of blood vessels that organises and sustains various microenvironments in bone. The recent identification of heterogeneity in the bone vasculature supports the existence of multiple vascular niches within the bone marrow compartment. A unique combination of cells and factors defining a particular microenvironment, supply regulatory signals to mediate a specific function. This review discusses recent developments in our understanding of vascular niches in bone that play a critical role in regulating the behaviour of multipotent haematopoietic and mesenchymal stem cells during development and homeostasis.
Issue Date: 17-Sep-2017
Date of Acceptance: 23-Aug-2017
URI: http://hdl.handle.net/10044/1/50490
DOI: https://dx.doi.org/10.1155/2017/5046953
ISSN: 1687-9678
Publisher: Hindawi Publishing Corporation
Journal / Book Title: Stem Cells International
Volume: 2017
Copyright Statement: Copyright © 2017 Saravana K. Ramasamy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Medical Research Council (MRC)
Wellcome Trust
Funder's Grant Number: P65820 - PO4050604937
202300/Z/16/Z
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell & Tissue Engineering
Cell Biology
HEMATOPOIETIC STEM-CELLS
EARLY MESENCHYMAL PROGENITORS
ENDOTHELIAL-CELLS
STROMAL CELLS
PERIVASCULAR NICHE
MINERAL METABOLISM
ENERGY-METABOLISM
MARROW NICHE
MICE LACKING
ANGIOGENESIS
Publication Status: Published
Article Number: 5046953
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine



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