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Models and tissue mimics for brain shift simulations

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BMMB-D-17-00054_R1.pdfAccepted version3.85 MBAdobe PDFView/Open
10.1007%2Fs10237-017-0958-7.pdfPublished version2.18 MBAdobe PDFView/Open
Title: Models and tissue mimics for brain shift simulations
Authors: Forte, AE
Galvan, S
Dini, D
Item Type: Journal Article
Abstract: Capturing the deformation of human brain during neurosurgical operations is an extremely important task to improve the accuracy or surgical procedure and minimize permanent damage in patients. This study focuses on the development of an accurate numerical model for the prediction of brain shift during surgical procedures and employs a tissue mimic recently developed to capture the complexity of the human tissue. The phantom, made of a composite hydrogel, was designed to reproduce the dynamic mechanical behaviour of the brain tissue in a range of strain rates suitable for surgical procedures. The use of a well-controlled, accessible and MRI compatible alternative to real brain tissue allows us to rule out spurious effects due to patient geometry and tissue properties variability, CSF amount uncertainties, and head orientation. The performance of different constitutive descriptions is evaluated using a brain–skull mimic, which enables 3D deformation measurements by means of MRI scans. Our combined experimental and numerical investigation demonstrates the importance of using accurate constitutive laws when approaching the modelling of this complex organic tissue and supports the proposal of a hybrid poro-hyper-viscoelastic material formulation for the simulation of brain shift.
Issue Date: 6-Sep-2017
Date of Acceptance: 22-Aug-2017
URI: http://hdl.handle.net/10044/1/50479
DOI: https://dx.doi.org/10.1007/s10237-017-0958-7
ISSN: 1617-7940
Publisher: Springer Verlag
Start Page: 249
End Page: 261
Journal / Book Title: Biomechanics and Modeling in Mechanobiology
Volume: 17
Issue: 1
Copyright Statement: © The Author(s) 2017. This article is an open access publication
Sponsor/Funder: Commission of the European Communities
Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: 270460
EP/K503733/1
EP/N025954/1
Keywords: Biomechanics
Brain phantom
Brain tissue
FE modelling
Image-guided surgery
Soft tissue
0913 Mechanical Engineering
0903 Biomedical Engineering
Biomedical Engineering
Publication Status: Published
Appears in Collections:Faculty of Engineering
Mechanical Engineering
Bioengineering
Faculty of Natural Sciences



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