Emerging roles of hnRNPA1 inmodulating malignanttransformation

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Title: Emerging roles of hnRNPA1 inmodulating malignanttransformation
Authors: Roy, R
Pardo, O
Seckl, M
Huang, Y
Item Type: Journal Article
Abstract: Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA-binding proteins associated with complex and diverse biological processes such as processing of heterogeneous nuclear RNAs (hnRNAs) into mature mRNAs, RNA splicing, transactivation of gene expression, and modulation of protein translation. hnRNPA1 is the most abundant and ubiquitously expressed member of this protein family and has been shown to be involved in multiple molecular events driving malignant transformation. In addition to selective mRNA splicing events promoting expression of specific protein variants, hnRNPA1 regulates the gene expression and translation of several key players associated with tumorigenesis and cancer progression. Here, we will summarize our current knowledge of the involvement of hnRNPA1 in cancer, including its roles in regulating cell proliferation, invasiveness, metabolism, adaptation to stress and immortalization.
Issue Date: 8-Aug-2017
Date of Acceptance: 22-May-2017
ISSN: 1757-7004
Publisher: Wiley
Journal / Book Title: Wiley Interdisciplinary Reviews: RNA
Volume: 8
Issue: 6
Copyright Statement: This is the peer reviewed version of the following article: Roy, R., Huang, Y., Seckl, M. J. and Pardo, O. E. (2017), Emerging roles of hnRNPA1 in modulating malignant transformation. WIREs RNA, e1431. doi:10.1002/wrna.1431, which has been published in final form at This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Publication Status: Published
Article Number: e1431
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine

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