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Gold Nanostar Substrates for Metal Enhanced Fluorescence through the First and Second Near-Infrared Windows

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Title: Gold Nanostar Substrates for Metal Enhanced Fluorescence through the First and Second Near-Infrared Windows
Authors: Theodorou, I
Jawad, Z
Jiang, Q
Aboagye, E
Porter, A
Ryan, M
Xie, F
Item Type: Journal Article
Abstract: Gold nanostars (AuNSs) are receiving increasing attention for their potential applications in bionanotechnology because of their unique optical properties related to their complex branched morphology. Their sharp features allow strong localized surface plasmon resonances, tunable in the near-infrared (NIR) region, and large enhancements of local electromagnetic fields. Here, the application of AuNSs in metal-enhanced fluorescence (MEF) in the NIR and second NIR (NIR-II) biological windows is explored for the first time. NIR/NIR-II fluorophores are incorporated onto monolayers of AuNSs with tunable plasmonic responses. Over 320-fold fluorescence enhancement is achieved in the NIR, confirming that AuNS substrates are promising NIR-MEF platforms for the development of ultrasensitive biosensing applications. Using fluorescence lifetime measurements to semiquantitatively deconvolute the excitation enhancement from emission enhancement, as well as modeling to simulate the electric field enhancement, we show that a combination of enhanced excitation and an increased radiative decay rate, accompanied by an increase in the quantum yield, contribute to the observed large enhancement. AuNSs with different morphological features exhibit significantly different excitation enhancements, indicating the important role of the particle morphology on the magnitude of electromagnetic field enhancement and the resulting enhancement factor. Importantly, enhancement factors of up to 50-fold are also achieved in the NIR-II region, suggesting that this system holds promise for the future development of bright probes for NIR/NIR-II biosensing and bioimaging.
Issue Date: 22-Aug-2017
Date of Acceptance: 3-Aug-2017
URI: http://hdl.handle.net/10044/1/50358
DOI: https://dx.doi.org/10.1021/acs.chemmater.7b02313
ISSN: 1520-5002
Publisher: American Chemical Society
Start Page: 6916
End Page: 6926
Journal / Book Title: Chemistry of Materials
Volume: 29
Issue: 16
Copyright Statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemistry of Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acs.chemmater.7b02313
Sponsor/Funder: British Council
Funder's Grant Number: 216239013
Keywords: 03 Chemical Sciences
09 Engineering
Materials
Publication Status: Published
Appears in Collections:Faculty of Engineering
Materials
Division of Surgery
Division of Cancer
Faculty of Medicine
Faculty of Natural Sciences



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