Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma

Title: Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma
Authors: Matsuo, K
Wong, K-K
Fotopoulou, C
Blake, EA
Robertson, SE
Pejovic, T
Frimer, M
Pardeshi, V
Hu, W
Choi, J-S
Sun, CC
Richmond, AM
Marcus, JZ
Hilliard, MAM
Mostofizadeh, S
Mhawech-Fauceglia, P
Abdulfatah, E
Post, MD
Shahzad, MMK
Karabakhtsian, RG
Ali-Fehmi, R
Gabra, H
Roman, LD
Sood, AK
Gershenson, DM
Item Type: Journal Article
Abstract: BACKGROUND AND OBJECTIVES: To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival of women with low-grade serous ovarian carcinoma containing areas of LVSI. METHODS: This is a multicenter retrospective study examining consecutive cases of surgically treated stage I-IV low-grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico-pathological findings and survival outcome. RESULTS: LVSI was seen in 79 cases (44.4%, 95% confidence interval [CI] 37.1-51.7). LVSI was associated with increased risk of omental metastasis (87.0% vs 64.9%, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9% vs 0%, P = 0.012), and malignant ascites (49.3% vs 32.6%, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression-free survival (5-year rates 21.0% vs 35.7%, adjusted-hazard ratio 1.57, 95%CI 1.06-2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95%CI 1.08-6.35, P = 0.047). CONCLUSION: LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma.
Issue Date: 8-Aug-2017
Date of Acceptance: 19-Jul-2017
URI: http://hdl.handle.net/10044/1/50302
DOI: https://dx.doi.org/10.1002/jso.24801
ISSN: 1096-9098
Publisher: Wiley
Start Page: 236
End Page: 244
Journal / Book Title: Journal of Surgical Oncology
Volume: 117
Issue: 2
Copyright Statement: © 2017 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Matsuo K, Wong K-K, Fotopoulou C, et al. Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma. J Surg Oncol. 2017; 9999:1–9. https://doi.org/10.1002/jso.24801, which has been published in final form at https://dx.doi.org/10.1002/jso.24801. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Sponsor/Funder: Ovarian Cancer Action
Funder's Grant Number: N/A
Keywords: low-grade serous
lymphovascular space invasion
ovarian cancer
1112 Oncology And Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published online
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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