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Modelling somatic and dendritic spike mediated plasticity at the single neuron and network level

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Title: Modelling somatic and dendritic spike mediated plasticity at the single neuron and network level
Authors: Bono, J
Clopath, C
Item Type: Journal Article
Abstract: Synaptic plasticity is thought to be the principal neuronal mechanism underlying learning. Models of plastic networks typically combine point neurons with spike-timing-dependent plasticity (STDP) as the learning rule. However, a point neuron does not capture the local non-linear processing of synaptic inputs allowed for by dendrites. Furthermore, experimental evidence suggests that STDP is not the only learning rule available to neurons. By implementing biophysically realistic neuron models, we study how dendrites enable multiple synaptic plasticity mechanisms to coexist in a single cell. In these models, we compare the conditions for STDP and for synaptic strengthening by local dendritic spikes. We also explore how the connectivity between two cells is affected by these plasticity rules and by different synaptic distributions. Finally, we show that how memory retention during associative learning can be prolonged in networks of neurons by including dendrites.
Issue Date: 26-Sep-2017
Date of Acceptance: 25-Jul-2017
URI: http://hdl.handle.net/10044/1/50243
DOI: https://dx.doi.org/10.1038/s41467-017-00740-z
ISSN: 2041-1723
Publisher: Nature Publishing Group: Nature Communications
Journal / Book Title: Nature Communications
Volume: 8
Copyright Statement: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2017
Sponsor/Funder: The Leverhulme Trust
Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Funder's Grant Number: RPG-2015-171
200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Keywords: MD Multidisciplinary
Publication Status: Published
Article Number: 706
Appears in Collections:Faculty of Engineering
Bioengineering



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