Altmetric

The search for biomarkers of long-term outcome after preterm birth

Title: The search for biomarkers of long-term outcome after preterm birth
Authors: Parkinson, JRC
Hyde, MJ
Modi, N
Item Type: Conference Paper
Abstract: Preterm birth and survival rates are rising globally, and consequently there is a growing necessity to safeguard life-long health. Epidemiological and other studies from around the world point to a higher risk of adverse adult health outcomes following preterm birth. These reports encompass morbidities in multiple domains, poorer reproductive health, and reduced longevity. The contributions of genetic inheritance, intrauterine exposures, and postnatal care practices to this altered adult phenotype are not known. Early detection is essential to implement preventive measures and to test protective antenatal and neonatal interventions to attenuate aberrant health trajectories. A satisfactory biomarker of outcome must be predictive of later functional health and ideally remain stable over the period from infancy to childhood and adult life. To date, blood pressure is the index that best fulfils these criteria. High throughput ‘omic' technologies may identify biomarkers of later outcome and health risk. However, their potential can only be realized with initial investment in large, longitudinal cohort studies, which couple serial metabolomic profiling with functional health assessments across the life course.
Editors: Baetge, EE
Dhawan, A
Prentice, AM
Issue Date: 1-Jan-2016
Date of Acceptance: 23-Sep-2014
URI: http://hdl.handle.net/10044/1/50188
DOI: https://dx.doi.org/10.1159/000436957
ISBN: 978-3-318-05598-6
ISSN: 1664-2147
Publisher: Karger
Start Page: 71
End Page: 80
Journal / Book Title: Next-Generation Nutritional Biomarkers to Guide Better Health Care
Volume: 84
Copyright Statement: © 2016 Nestec Ltd., Vevey/S. Karger AG, Basel
Sponsor/Funder: British Heart Foundation
Funder's Grant Number: PG/13/49/30307
Conference Name: 84th Nestle-Nutrition-Institute Workshop on Next-Generation Nutritional Biomarkers to Guide Better Health Care
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Nutrition & Dietetics
CORONARY-HEART-DISEASE
BLOOD-PRESSURE
CARDIOVASCULAR RISK
METABOLIC SYNDROME
CHILDHOOD OBESITY
YOUNG ADULTHOOD
GESTATIONAL-AGE
BORN PRETERM
METAANALYSIS
MORTALITY
Adult
Biomarkers
Blood Pressure
Early Diagnosis
Female
Humans
Infant, Newborn
Pregnancy
Premature Birth
Risk Factors
Publication Status: Published
Start Date: 2014-09-23
Finish Date: 2014-09-25
Conference Place: Lausanne, SWITZERLAND
Open Access location: https://www.ncbi.nlm.nih.gov/pubmed/26764475
Appears in Collections:Department of Medicine



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx