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Engineering compartmentalized biomimetic micro- and nanocontainers

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Title: Engineering compartmentalized biomimetic micro- and nanocontainers
Authors: Trantidou, T
Friddin, M
Elani, Y
Brooks, NJ
Law, RV
Seddon, JM
Ces, O
Item Type: Journal Article
Abstract: Compartmentalization of biological content and function is a key architectural feature in biology, where membrane bound micro- and nanocompartments are used for performing a host of highly specialized and tightly regulated biological functions. The benefit of compartmentalization as a design principle is behind its ubiquity in cells and has led to it being a central engineering theme in construction of artificial cell-like systems. In this review, we discuss the attractions of designing compartmentalized membrane-bound constructs and review a range of biomimetic membrane architectures that span length scales, focusing on lipid-based structures but also addressing polymer-based and hybrid approaches. These include nested vesicles, multicompartment vesicles, large-scale vesicle networks, as well as droplet interface bilayers, and double-emulsion multiphase systems (multisomes). We outline key examples of how such structures have been functionalized with biological and synthetic machinery, for example, to manufacture and deliver drugs and metabolic compounds, to replicate intracellular signaling cascades, and to demonstrate collective behaviors as minimal tissue constructs. Particular emphasis is placed on the applications of these architectures and the state-of-the-art microfluidic engineering required to fabricate, functionalize, and precisely assemble them. Finally, we outline the future directions of these technologies and highlight how they could be applied to engineer the next generation of cell models, therapeutic agents, and microreactors, together with the diverse applications in the emerging field of bottom-up synthetic biology.
Issue Date: 28-Jun-2017
Date of Acceptance: 28-Jun-2017
URI: http://hdl.handle.net/10044/1/49804
DOI: https://dx.doi.org/10.1021/acsnano.7b03245
ISSN: 1936-086X
Publisher: American Chemical Society
Start Page: 6549
End Page: 6565
Journal / Book Title: ACS Nano
Volume: 11
Issue: 7
Copyright Statement: © 2017 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
compartmentalization
artificial cells
synthetic biology
lipid membrane
vesicles
polymersomes
double emulsions
droplet interface bilayers
microfluidics
MONODISPERSE DOUBLE EMULSIONS
GIANT UNILAMELLAR VESICLES
INTERFACE BILAYER NETWORKS
ENZYME-LOADED LIPOSOMES
ARTIFICIAL CELLS
LIPID VESICLES
DRUG-DELIVERY
IN-OIL
MEMBRANE CURVATURE
DROPLET NETWORKS
MD Multidisciplinary
Publication Status: Published
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Faculty of Natural Sciences



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