Road traffic noise and incident cardiovascular disease: a joint analysis of HUNT, EPIC-Oxford and UK Biobank

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Title: Road traffic noise and incident cardiovascular disease: a joint analysis of HUNT, EPIC-Oxford and UK Biobank
Author(s): Cai, Y
Hodgson, S
Blangiardo, M
Gulliver, J
Morley, D
Vienneau, D
De Hoogh, K
Key, T
Hveem, K
Elliott, P
Hansell, A
Item Type: Conference Paper
Abstract: Aims: This study aimed to investigate the effects of long-term exposure to road traffic noise on incident CVD in three large cohorts: HUNT, EPIC-Oxford and UK Biobank. Methods: In a complete-case sample (N=361,699), 4,014 IHD and 2,109 cerebrovascular incident cases were ascertained between baseline (1993-2010) and end of follow-up (2008- 2015) through medical record linkage. Annual mean road traffic noise exposure was modelled at baseline address. Individual-level covariate data were harmonised and data were pooled. Analyses used Cox proportional hazards model with adjustments for confounders, including air pollution. Results: For an interquartile range (IQR) (3.9 dBA) higher daytime noise, a non-significant association with incident IHD was seen (Hazard ratio (HR): 1.015, 95% Confidence Interval (CI): 0.989-1.042), fully adjusted. Statistically significant associations and interaction terms were seen in obese individuals (HR: 1.099, 95%CI: 1.029-1.174), and current-smokers (HR: 1.054, 95%CI: 1.007-1.103). No associations were found for ischemic or hemorrhagic stroke. Conclusions: Our study strengthens the evidence base for an effect of road traffic noise on incident IHD, whilst the association with incident stroke remains unclear.
Publication Date: 18-Jun-2017
Date of Acceptance: 18-Jun-2017
URI: http://hdl.handle.net/10044/1/49799
Publisher: International Commission on Biological Effects of Noise
Journal / Book Title: ICBEN 2017 Proceedings
Copyright Statement: © 2017 ICBEN
Sponsor/Funder: Medical Research Council (MRC)
EU FP7
Public Health England
Medical Research Council
Funder's Grant Number: MR/L01341X/1
6509268
Conference Name: ICBEN Congress on Noise as a Public Health Problem
Publication Status: Published
Start Date: 2017-06-18
Finish Date: 2017-06-22
Conference Place: Zurich, Switzerland
Open Access location: http://www.icben.org/2017/ICBEN%202017%20Papers/SubjectArea03_Hansell_0315_3910.pdf
Appears in Collections:Epidemiology, Public Health and Primary Care



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