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A systematic review of definitions of extreme phenotypes of HIV control and progression

Title: A systematic review of definitions of extreme phenotypes of HIV control and progression
Authors: Gurdasani, D
Iles, L
Dillon, DG
Young, EH
Olson, AD
Naranbhai, V
Fidler, S
Gkrania-Klotsas, E
Post, FA
Kellam, P
Porter, K
Sandhu, MS
Item Type: Journal Article
Abstract: The study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable insights into HIV biology. Heterogeneity in criteria used to define these individuals can introduce inconsistencies in results from research and make it difficult to identify biological mechanisms underlying these phenotypes. In this systematic review, we formally quantified the heterogeneity in definitions used for terms referring to extreme phenotypes in the literature, and identified common definitions and components used to describe these phenotypes. We assessed 714 definitions of HIV extreme phenotypes in 501 eligible studies published between 1 January 2000 and 15 March 2012, and identified substantial variation among these. This heterogeneity in definitions may represent important differences in biological endophenotypes and clinical progression profiles of individuals selected by these, suggesting the need for harmonized definitions. In this context, we were able to identify common components in existing definitions that may provide a framework for developing consensus definitions for these phenotypes in HIV infection.
Issue Date: 14-Jan-2014
Date of Acceptance: 29-Aug-2013
URI: http://hdl.handle.net/10044/1/49796
DOI: https://dx.doi.org/10.1097/QAD.0000000000000049
ISSN: 0269-9370
Publisher: Lippincott, Williams & Wilkins
Start Page: 149
End Page: 162
Journal / Book Title: AIDS
Volume: 28
Issue: 2
Copyright Statement: © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License (https://creativecommons.org/licenses/by-nc-nd/3.0/), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Virology
IMMUNOLOGY
INFECTIOUS DISEASES
VIROLOGY
definitions
elite controllers
extreme-trait designs
HIV
HIV controllers
long-term nonprogressors
phenotypes
slow progressors
systematic review
viremic controllers
LONG-TERM NONPROGRESSORS
REGULATORY T-CELLS
SLOW PROGRESSORS
ANTIRETROVIRAL THERAPY
CLASS-I
INFECTION
COHORT
AIDS
ASSOCIATION
GENE
Disease Progression
HIV Infections
HIV Long-Term Survivors
Humans
Phenotype
Terminology as Topic
06 Biological Sciences
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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