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Hypothalamic-pituitary axis regulates hydrogen sulfide production

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Title: Hypothalamic-pituitary axis regulates hydrogen sulfide production
Authors: Hine, C
Kim, H-J
Zhu, Y
Harputlugil, E
Longchamp, A
Matos, MS
Ramadoss, P
Bauerle, K
Brace, L
Asara, JM
Ozaki, CK
Cheng, S-Y
Singha, S
Ahn, KH
Kimmelman, A
Fisher, FM
Pissios, P
Withers, DJ
Selman, C
Wang, R
Yen, K
Longo, VD
Cohen, P
Bartke, A
Kopchick, JJ
Miller, R
Hollenberg, AN
Mitchell, JR
Item Type: Journal Article
Abstract: Decreased growth hormone (GH) and thyroid hormone (TH) signaling are associated with longevity and metabolic fitness. The mechanisms underlying these benefits are poorly understood, but may overlap with those of dietary restriction (DR), which imparts similar benefits. Recently we discovered that hydrogen sulfide (H2S) is increased upon DR and plays an essential role in mediating DR benefits across evolutionary boundaries. Here we found increased hepatic H2S production in long-lived mouse strains of reduced GH and/or TH action, and in a cell-autonomous manner upon serum withdrawal in vitro. Negative regulation of hepatic H2S production by GH and TH was additive and occurred via distinct mechanisms, namely direct transcriptional repression of the H2S-producing enzyme cystathionine γ-lyase (CGL) by TH, and substrate-level control of H2S production by GH. Mice lacking CGL failed to downregulate systemic T4 metabolism and circulating IGF-1, revealing an essential role for H2S in the regulation of key longevity-associated hormones.
Issue Date: 9-Jun-2017
Date of Acceptance: 11-May-2017
URI: http://hdl.handle.net/10044/1/49755
DOI: https://dx.doi.org/10.1016/j.cmet.2017.05.003
ISSN: 1550-4131
Publisher: Elsevier
Start Page: 1320
End Page: +
Journal / Book Title: Cell Metabolism
Volume: 25
Issue: 6
Copyright Statement: © 2017 The Authors. Published by Elsevier Inc. Thi is an open access article under a CC-BY license (https://creativecommons.org/licenses/by/4.0/)
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 098565/Z/12/Z
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
Endocrinology & Metabolism
CYSTATHIONINE-GAMMA-LYASE
THYROID-HORMONE RECEPTOR
LIFE-SPAN EXTENSION
LIVED MUTANT MICE
AMES DWARF MICE
GROWTH-FACTOR I
GENE-EXPRESSION
CALORIE RESTRICTION
STRESS RESISTANCE
DIETARY RESTRICTION
FGF21
IGF-1
IRS-1
autophagy
cystathionine γ-lyase
growth hormone
hydrogen sulfide
hypopituitary dwarfism
longevity
thyroid hormone
0601 Biochemistry And Cell Biology
1101 Medical Biochemistry And Metabolomics
Publication Status: Published
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine



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