Consumptiion of fruits,vegetables, and fruit juices and differentiated thyroid carcinoma risk in the European Investigation into Cancer and Nutrition (EPIC) study

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Title: Consumptiion of fruits,vegetables, and fruit juices and differentiated thyroid carcinoma risk in the European Investigation into Cancer and Nutrition (EPIC) study
Authors: Zamora-Ros, R
Beraud, V
Franceschi, S
Cayssials, V
Tsilidis, KK
Boutron-Ruault, MC
Weiderpass, E
Overvad, K
Tjonneland, A
Eriksen, AK
Bonnet, F
Affret, A
Katzke, V
Kuhn, T
Boeing, H
Trichopoulou, A
Valanou, E
Karakatsani, A
Masala, G
Grioni, S
Santucci de Magistris, M
Tumino, R
Ricceri, F
Skeie, G
Parr, CL
Merino, S
Salamanca-Fernandez, E
Chirlaque, MD
Ardanaz, E
Amiano, P
Almquist, M
Drake, I
Hennings, J
Sandstrom, M
Bueno-de-Mesquita, HB
Peeters, PH
Khaw, KT
Wareham, NJ
Schmidt, JA
Perez-Cornago, A
Aune, D
Riboli, E
Slimani, N
Scalbert, A
Romieu, I
Agudo, A
Rinaldi, S
Item Type: Journal Article
Abstract: Fruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000. During a mean follow-up of 14 years, 748 incident first primary differentiated TC cases were identified. F&V and fruit juice intakes were assessed through validated country-specific dietary questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Comparing the highest versus lowest quartile of intake, differentiated TC risk was not associated with intakes of total F&V (HR: 0.89; 95% CI: 0.68–1.15; p-trend = 0.44), vegetables (HR: 0.89; 95% CI: 0.69–1.14; p-trend = 0.56), or fruit (HR: 1.00; 95% CI: 0.79–1.26; p-trend = 0.64). No significant association was observed with any individual type of vegetable or fruit. However, there was a positive borderline trend with fruit juice intake (HR: 1.23; 95% CI: 0.98–1.53; p-trend = 0.06). This study did not find any significant association between F&V intakes and differentiated TC risk; however a positive trend with fruit juice intake was observed, possibly related to its high sugar content.
Issue Date: 24-Jul-2017
Date of Acceptance: 20-Jun-2017
ISSN: 1097-0215
Publisher: Wiley
Start Page: 449
End Page: 459
Journal / Book Title: International Journal of Cancer
Volume: 142
Issue: 3
Copyright Statement: © 2017 UICC. This is the accepted version of the following article, which has been published in final form at
Sponsor/Funder: Imperial College Trust
Funder's Grant Number: P47328
Keywords: EPIC
fruit juices
thyroid cancer
Cohort Studies
Fruit and Vegetable Juices
Healthy Diet
Middle Aged
Prospective Studies
Thyroid Neoplasms
1112 Oncology And Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care

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