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Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging

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Title: Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging
Authors: Lin, S
Shah, A
Hernández-Gil, J
Stanziola, A
Harriss, BI
Matsunaga, TO
Long, N
Bamber, J
Tang, M-X
Item Type: Journal Article
Abstract: We demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration. It is manufactured via a 'microbubble condensation' method. The phase-transition of Cy-droplets can be optically triggered by pulsed-laser illumination, inducing photoacoustic signal and forming stable gas bubbles that are visible with echo-ultrasound in situ. Alternatively, Cy-droplets can be converted to microbubble contrast agents upon acoustic activation with clinical ultrasound. Potentially all modes offer extravascular contrast enhancement because of the sub-micron initial size. Such versatility of acoustic and optical 'triggerability' can potentially improve multi-modality imaging, molecularly targeted imaging and controlled drug release.
Issue Date: 11-Apr-2017
Date of Acceptance: 8-Apr-2017
URI: http://hdl.handle.net/10044/1/49514
DOI: https://dx.doi.org/10.1016/j.pacs.2017.04.001
ISSN: 2213-5979
Publisher: Elsevier
Start Page: 26
End Page: 36
Journal / Book Title: Photoacoustics
Volume: 6
Copyright Statement: © 2017 The Authors. Published by Elsevier GmbH. This is an open access article under the CC-BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Droplet
Microbubble
Multispectral optoacoustic tomography (MSOT)
Optical/acoustic vaporisation
Phase-change contrast agent
Photoacoustic
Ultrasound
Publication Status: Published online
Conference Place: Germany
Appears in Collections:Bioengineering
Chemistry
Catalysis and Advanced Materials
Faculty of Natural Sciences



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