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Carbohydrates, glycemic index, glycemic load, and breast cancer risk: a systematic review and dose-response meta-analysis of prospective studies

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Title: Carbohydrates, glycemic index, glycemic load, and breast cancer risk: a systematic review and dose-response meta-analysis of prospective studies
Authors: Schlesinger, S
Chan, DSM
Vingeliene, S
Vieira, AR
Abar, L
Polemiti, E
Stevens, CAT
Greenwood, DC
Aune, D
Norat, T
Item Type: Journal Article
Abstract: Context: The investigation of dose–response associations between carbohydrate intake, glycemic index, glycemic load, and risk of breast cancer stratified by menopausal status, hormone receptor status, and body mass index (BMI) remains inconclusive. Objective: A systematic review and dose–response meta-analyses was conducted to investigate these associations. Data Sources: As part of the World Cancer Research Fund/American Institute for Cancer Research Continuous Update Project, PubMed was searched up to May 2015 for relevant studies on these associations. Study Selection: Prospective studies reporting associations between carbohydrate intake, glycemic index, or glycemic load and breast cancer risk were included. Data Extraction: Two investigators independently extracted data from included studies. Results: Random-effects models were used to summarize relative risks (RRs) and 95%CIs. Heterogeneity between subgroups, including menopausal status, hormone receptor status, and BMI was explored using meta-regression. Nineteen publications were included. The summary RRs (95%CIs) for breast cancer were 1.04 (1.00–1.07) per 10 units/d for glycemic index, 1.01 (0.98–1.04) per 50 units/d for glycemic load, and 1.00 (0.96–1.05) per 50 g/d for carbohydrate intake. For glycemic index, the association appeared slightly stronger among postmenopausal women (summary RR per 10 units/d, 1.06; 95%CI, 1.02–1.10) than among premenopausal women, though the difference was not statistically significant (Pheterogeneity = 0.15). Glycemic load and carbohydrate intake were positively associated with breast cancer among postmenopausal women with estrogen-negative tumors (summary RR for glycemic load, 1.28; 95%CI, 1.08–1.52; and summary RR for carbohydrates, 1.13; 95%CI, 1.02–1.25). No differences in BMI were detected. Conclusions: Menopausal and hormone receptor status, but not BMI, might be potential influencing factors for the associations between carbohydrate intake, glycemic index, glycemic load, and breast cancer.
Issue Date: 29-May-2017
Date of Acceptance: 1-May-2017
URI: http://hdl.handle.net/10044/1/49359
DOI: https://dx.doi.org/10.1093/nutrit/nux010
ISSN: 0029-6643
Publisher: Oxford University Press
Start Page: 420
End Page: 441
Journal / Book Title: NUTRITION REVIEWS
Volume: 75
Issue: 6
Copyright Statement: © 2017 The Author(s). Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. This is a pre-copy-editing, author-produced version of an article accepted for publication in Nutrition Reviews following peer review. The definitive publisher-authenticated version Sabrina Schlesinger, Doris S.M. Chan, Snieguole Vingeliene, Ana R. Vieira, Leila Abar, Elli Polemiti, Christophe A.T. Stevens, Darren C. Greenwood, Dagfinn Aune, Teresa Norat; Carbohydrates, glycemic index, glycemic load, and breast cancer risk: a systematic review and dose–response meta-analysis of prospective studies, Nutrition Reviews, Volume 75, Issue 6, 1 June 2017, Pages 420–441, https://doi.org/10.1093/nutrit/nux010 is available online at: https://dx.doi.org/10.1093/nutrit/nux010
Keywords: Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
breast cancer
carbohydrates
glycemic index
glycemic load
meta-analysis
systematic review
HORMONE-RECEPTOR STATUS
C-REACTIVE PROTEIN
PROSPECTIVE COHORT
DIETARY-FAT
POSTMENOPAUSAL WOMEN
ADOLESCENT DIET
NUTRITION
DISEASE
FIBER
PATTERNS
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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