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On the choice of outlet boundary conditions for patient-specific analysis of aortic flow using computational fluid dynamics

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Title: On the choice of outlet boundary conditions for patient-specific analysis of aortic flow using computational fluid dynamics
Authors: Pirola, S
Cheng, Z
Jarral, OA
O'Regan, DP
Pepper, JR
Athanasiou, T
Xu, XY
Item Type: Journal Article
Abstract: Boundary conditions (BCs) are an essential part in computational fluid dynamics (CFD) simulations of blood flow in large arteries. Although several studies have investigated the influence of BCs on predicted flow patterns and hemodynamic wall parameters in various arterial models, there is a lack of comprehensive assessment of outlet BCs for patient-specific analysis of aortic flow. In this study, five different sets of outlet BCs were tested and compared using a subject-specific model of a normal aorta. Phase-contrast magnetic resonance imaging (PC-MRI) was performed on the same subject and velocity profiles extracted from the in vivo measurements were used as the inlet boundary condition. Computational results obtained with different outlet BCs were assessed in terms of their agreement with the PC-MRI velocity data and key hemodynamic parameters, such as pressure and flow waveforms and wall shear stress related indices. Our results showed that the best overall performance was achieved by using a well-tuned three-element Windkessel model at all model outlets, which not only gave a good agreement with in vivo flow data, but also produced physiological pressure waveforms and values. On the other hand, opening outlet BCs with zero pressure at multiple outlets failed to reproduce any physiologically relevant flow and pressure features.
Issue Date: 20-Jun-2017
Date of Acceptance: 14-Jun-2017
URI: http://hdl.handle.net/10044/1/49297
DOI: https://dx.doi.org/10.1016/j.jbiomech.2017.06.005
ISSN: 1873-2380
Publisher: Elsevier
Start Page: 15
End Page: 21
Journal / Book Title: Journal of Biomechanics
Volume: 60
Copyright Statement: © 2017 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Commission of the European Communities
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: 642458
RDC04
Keywords: Aorta
Boundary conditions
Computational fluid dynamics (CFD)
Hemodynamics
Patient-specific simulation
Windkessel model
0903 Biomedical Engineering
1106 Human Movement And Sports Science
0913 Mechanical Engineering
Biomedical Engineering
Publication Status: Published
Appears in Collections:Faculty of Engineering
Division of Surgery
Clinical Sciences
Imaging Sciences
National Heart and Lung Institute
Chemical Engineering
Faculty of Medicine



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