New and repurposed drugs for pediatric multidrug-resistant tuberculosis practice-based recommendations

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Title: New and repurposed drugs for pediatric multidrug-resistant tuberculosis practice-based recommendations
Author(s): Harausz, EP
Garcia-Prats, AJ
Seddon, JA
Schaaf, HS
Hesseling, AC
Achar, J
Bernheimer, J
Cruz, AT
D'Ambrosio, L
Detjen, A
Graham, SM
Hughes, J
Jonckheere, S
Marais, BJ
Migliori, GB
McKenna, L
Skrahina, A
Tadolini, M
Wilson, P
Furin, J
Item Type: Journal Article
Abstract: It is estimated that 33,000 children develop multidrug-resistant tuberculosis (MDR-TB) each year. In spite of these numbers, children and adolescents have limited access to the new and repurposed MDR-TB drugs. There is also little clinical guidance for the use of these drugs and for the shorter MDR-TB regimen in the pediatric population. This is despite the fact that these drugs and regimens are associated with improved interim outcomes and acceptable safety profiles in adults. This review fills a gap in the pediatric MDR-TB literature by providing practice-based recommendations for the use of the new (delamanid and bedaquiline) and repurposed (linezolid and clofazimine) MDR-TB drugs and the new shorter MDR-TB regimen in children and adolescents.
Publication Date: 15-May-2017
Date of Acceptance: 8-Nov-2016
URI: http://hdl.handle.net/10044/1/49103
DOI: https:dx.doi.org/10.1164/rccm.201606-1227CI
ISSN: 1535-4970
Publisher: American Thoracic Society
Start Page: 1300
End Page: 1310
Journal / Book Title: American Journal of Respiratory and Critical Care Medicine
Volume: 195
Issue: 10
Copyright Statement: © 2017 by the American Thoracic Society.
Keywords: Science & Technology
Life Sciences & Biomedicine
Critical Care Medicine
Respiratory System
General & Internal Medicine
multidrug-resistant tuberculosis
Mycobacterium tuberculosis
child
adolescent
pediatric
COMPASSIONATE USE
XDR-TB
CHILDREN
BEDAQUILINE
DELAMANID
METAANALYSIS
REGIMEN
COHORT
TOLERABILITY
PROLONGATION
Mycobacterium tuberculosis
adolescent
child
multidrug-resistant tuberculosis
pediatric
Adolescent
Antitubercular Agents
Child
Humans
Practice Guidelines as Topic
Tuberculosis, Multidrug-Resistant
Science & Technology
Life Sciences & Biomedicine
Critical Care Medicine
Respiratory System
General & Internal Medicine
multidrug-resistant tuberculosis
Mycobacterium tuberculosis
child
adolescent
pediatric
COMPASSIONATE USE
XDR-TB
CHILDREN
BEDAQUILINE
DELAMANID
METAANALYSIS
REGIMEN
COHORT
TOLERABILITY
PROLONGATION
Respiratory System
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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