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Oligonucleotide-Lipid Conjugates Forming G-Quadruplex Structures Are Potent and Pangenotypic Hepatitis C Virus Entry Inhibitors In Vitro and Ex Vivo

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Title: Oligonucleotide-Lipid Conjugates Forming G-Quadruplex Structures Are Potent and Pangenotypic Hepatitis C Virus Entry Inhibitors In Vitro and Ex Vivo
Authors: Koutsoudakis, G
Paris de Leon, A
Herrera, C
Dorner, M
Perez-Vilaro, G
Lyonnais, S
Grijalvo, S
Eritja, R
Meyerhans, A
Mirambeau, G
Diez, J
Item Type: Journal Article
Abstract: A hepatitis C virus (HCV) epidemic affecting HIV-infected men who have sex with men (MSM) is expanding worldwide. In spite of the improved cure rates obtained with the new direct-acting antiviral drug (DAA) combinations, the high rate of reinfection within this population calls urgently for novel preventive interventions. In this study, we determined in cell culture and ex vivo experiments with human colorectal tissue that lipoquads, G-quadruplex DNA structures fused to cholesterol, are efficient HCV pangenotypic entry and cell-to-cell transmission inhibitors. Thus, lipoquads may be promising candidates for the development of rectally applied gels to prevent HCV transmission.
Issue Date: 1-May-2017
Date of Acceptance: 7-Feb-2017
URI: http://hdl.handle.net/10044/1/48707
DOI: https://dx.doi.org/10.1128/AAC.02354-16
ISSN: 0066-4804
Publisher: American Society for Microbiology
Journal / Book Title: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume: 61
Issue: 5
Copyright Statement: © 2017 American Society for Microbiology. All Rights Reserved.
Sponsor/Funder: Wellcome Trust
Commission of the European Communities
Funder's Grant Number: 104771/Z/14/Z
637304
Keywords: Science & Technology
Life Sciences & Biomedicine
Microbiology
Pharmacology & Pharmacy
oligonucleotide-cholesterol conjugates
DNA G-quadruplex structures
antiviral treatment
HCV entry inhibitor
HCV cell-to-cell inhibitor
HCV pangenotypic inhibitor
DENSITY-LIPOPROTEIN RECEPTOR
TO-CELL TRANSMISSION
B TYPE-I
NEUTRALIZING ANTIBODIES
SCAVENGER RECEPTOR
HEPATOMA-CELLS
L-SIGN
HYPERVARIABLE REGION-1
REPORTER VIRUSES
ENVELOPE PROTEIN
0605 Microbiology
1108 Medical Microbiology
1115 Pharmacology And Pharmaceutical Sciences
Publication Status: Published
Article Number: ARTN e02354-16
Appears in Collections:Department of Medicine
Faculty of Medicine



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