Coffee drinking and mortality in 10 European countries: a multinational cohort Study

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Title: Coffee drinking and mortality in 10 European countries: a multinational cohort Study
Author(s): Gunter, MJ
Murphy, N
Cross, A
Dossus, L
Dartois, L
Fagherazzzi, G
Kaaks, R
Kuhn, T
Boeing, H
Aleksandrova, K
Tjonneland, A
Olsen, A
Overvad, K
Larsen, SC
Redondo Cornejo, ML
Agudo, A
Sanchez Perez, MJ
Altzibar, JM
Navarro, C
Ardanaz, E
Khaw, KT
Butterworth, A
Bradbury, KE
Trichopoulou, A
Lagiou, P
Trichopoulos, D
Palli, D
Grioni, S
Vineis, P
Panico, S
Tumino, R
Bueno-de-Mesquita, B
Siersema, P
Landberg, R
Weiderpass, E
Skeie, G
Braaten, T
Brennan, P
Licaj, I
Muller, DC
Sinha, R
Wareham, N
Riboli, E
Item Type: Journal Article
Abstract: Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). Results: During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; γ-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels. Limitations: Reverse causality may have biased the findings; however, results did not differ after exclusion of participants who died within 8 years of baseline. Coffee-drinking habits were assessed only once. Conclusion: Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country.
Publication Date: 11-Jul-2017
Date of Acceptance: 18-May-2017
URI: http://hdl.handle.net/10044/1/48614
DOI: https://dx.doi.org/10.7326/M16-2945
ISSN: 1539-3704
Publisher: American College of Physicians
Start Page: 236
End Page: 247
Journal / Book Title: Annals of Internal Medicine
Volume: 167
Issue: 4
Copyright Statement: © 2017 American College of Physicians. All Rights Reserved.
Sponsor/Funder: Imperial College Trust
Funder's Grant Number: P47328
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
CORONARY HEART-DISEASE
C-REACTIVE PROTEIN
IOWA WOMENS HEALTH
CARDIOVASCULAR-DISEASE
OVARIAN-CANCER
DECAFFEINATED COFFEE
TEA CONSUMPTION
RISK-FACTORS
CAFFEINE
METAANALYSIS
Adult
Biomarkers
Cardiovascular Diseases
Cause of Death
Cerebrovascular Disorders
Coffee
Digestive System Diseases
Drinking
Europe
Female
Humans
Inflammation
Liver Function Tests
Male
Middle Aged
Mortality
Ovarian Neoplasms
Proportional Hazards Models
Prospective Studies
Risk Factors
Humans
Ovarian Neoplasms
Digestive System Diseases
Cerebrovascular Disorders
Cardiovascular Diseases
Inflammation
Liver Function Tests
Mortality
Cause of Death
Proportional Hazards Models
Risk Factors
Prospective Studies
Drinking
Coffee
Adult
Middle Aged
Europe
Female
Male
Biomarkers
11 Medical And Health Sciences
General & Internal Medicine
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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