Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

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Title: Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Author(s): Zamaros-Ros, R
Castandeda, J
Rinaldi, S
Cayssials, V
Slimani, N
Weiderpsas, E
Tsilidis, KK
Boutron-Ruault, MC
Overvad, K
Eriksen, AK
Tjonneland, A
Kuhn, T
Katzke, V
Boeing, H
Trichopoulou, A
La Vecchia, C
Kotanidou, A
Palli, D
Grioni, S
Mattiello, A
Tumino, R
Sciannameo, V
Lund, E
Merino, S
Salamanca-Fernandez, E
Amiano, P
Huerta, JM
Barricarte, A
Ericson, U
Almquist, M
Hennings, J
Sandstrom, M
Bueno-de-Mesquita, HB
Peeters, PH
Khaw, KT
Wareham, NJ
Schmidt, JA
Cross, AJ
Riboli, E
Scalbert, A
Romieu, I
Agudo, A
Franceschi, S
Item Type: Journal Article
Abstract: Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk. Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: EPIC is a cohort of >500,000 men and women, mostly aged 35–70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using country-specific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95% CIs adjusted for many potential confounders, including dietary and nondietary factors. Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95% CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence. Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare.
Publication Date: 7-Jun-2017
Date of Acceptance: 8-May-2017
URI: http://hdl.handle.net/10044/1/48488
DOI: https://dx.doi.org/10.3945/​jn.117.247874
ISSN: 0022-3166
Publisher: American Society for Nutrition
Start Page: 1366
End Page: 1373
Journal / Book Title: Journal of Nutrition
Volume: 147
Issue: 7
Copyright Statement: © 2017 American Society for Nutrition.
Sponsor/Funder: Imperial College Trust
Funder's Grant Number: P47328
Keywords: EPIC
cohort
fish
intake
thyroid cancer
Nutrition & Dietetics
1111 Nutrition And Dietetics
0702 Animal Production
0908 Food Sciences
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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