Mitochondrial heterogeneity, metabolic scaling and cell death

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Title: Mitochondrial heterogeneity, metabolic scaling and cell death
Author(s): Aryaman, J
Hoitzing, H
Burgstaller, J
Johnston, I
Jones, NS
Item Type: Journal Article
Abstract: Heterogeneity in mitochondrial content has been previously suggested as a major contributor to cellular noise, with multiple studies indicating its direct involvement in biomedically important cellular phenomena. A recently published dataset explored the connection between mitochondrial functionality and cell physiology, where a non-linearity between mitochondrial functionality and cell size was found. Using mathematical models, we suggest that a combination of metabolic scaling and a simple model of cell death may account for these observations. However, our findings also suggest the existence of alternative competing hypotheses, such as a non-linearity between cell death and cell size. While we find that the proposed non-linear coupling between mitochondrial functionality and cell size provides a compelling alternative to previous attempts to link mitochondrial heterogeneity and cell physiology, we emphasise the need to account for alternative causal variables, including cell cycle, size, mitochondrial density and death, in future studies of mitochondrial physiology.
Publication Date: 8-Jun-2017
Date of Acceptance: 5-May-2017
URI: http://hdl.handle.net/10044/1/48451
DOI: https://dx.doi.org/10.1002/bies.201700001
ISSN: 1521-1878
Publisher: Wiley-VCH Verlag
Journal / Book Title: Bioessays
Volume: 39
Issue: 7
Copyright Statement: © 2017 The Authors. BioEssays Published by WILEY Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Medical Research Council (MRC)
Engineering & Physical Science Research Council (EPSRC)
BBSRC DTP
Funder's Grant Number: MR/J013617/1
EP/N014529/1
BB/J014575/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Biology
Life Sciences & Biomedicine - Other Topics
cell death
cell size
heterogeneity
metabolic scaling
mitochondria
mitochondrial membrane potential
STOCHASTIC GENE-EXPRESSION
SINGLE-CELL
CANCER-CELLS
MEMBRANE
NOISE
MODEL
SIZE
SEGREGATION
VARIABILITY
POPULATIONS
Developmental Biology
06 Biological Sciences
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status: Published
Article Number: 1700001
Appears in Collections:Mathematics
Applied Mathematics and Mathematical Physics
Faculty of Natural Sciences



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