Artificial cell mimics as simplified models for the study of cell biology

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Title: Artificial cell mimics as simplified models for the study of cell biology
Author(s): Salehi-Reyhani, A
Ces, O
Elani, Y
Item Type: Journal Article
Abstract: Living cells are hugely complex chemical systems composed of a milieu of distinct chemical species (including DNA, proteins, lipids, and metabolites) interconnected with one another through a vast web of interactions: this complexity renders the study of cell biology in a quantitative and systematic manner a difficult task. There has been an increasing drive towards the utilization of artificial cells as cell mimics to alleviate this, a development that has been aided by recent advances in artificial cell construction. Cell mimics are simplified cell-like structures, composed from the bottom-up with precisely defined and tunable compositions. They allow specific facets of cell biology to be studied in isolation, in a simplified environment where control of variables can be achieved without interference from a living and responsive cell. This mini-review outlines the core principles of this approach and surveys recent key investigations that use cell mimics to address a wide range of biological questions. It will also place the field in the context of emerging trends, discuss the associated limitations, and outline future directions of the field.
Publication Date: 4-Jun-2017
Date of Acceptance: 30-Apr-2017
URI: http://hdl.handle.net/10044/1/48385
DOI: https://dx.doi.org/10.1177/1535370217711441
ISSN: 1535-3702
Publisher: SAGE Publications (UK and US)
Start Page: 1309
End Page: 1317
Journal / Book Title: Experimental Biology and Medicine
Volume: 242
Issue: 13
Copyright Statement: © 2017 by the Society for Experimental Biology and Medicine. This is an open access article under a CC-BY Attribution Licence (https://creativecommons.org/licenses/by/3.0/)
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/N016998/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
Artificial cells
biomimetics
synthetic biology
biophysics
LIQUID-DISORDERED DOMAINS
IN-VITRO
SYNTHETIC BIOLOGY
GENE-EXPRESSION
LIPID VESICLES
MEMBRANE CURVATURE
MECHANICAL-PROPERTIES
BENDING RIGIDITY
GIANT VESICLES
RNA SYNTHESIS
Artificial cells
biomimetics
biophysics
synthetic biology
Artificial Cells
Cell Physiological Phenomena
Cytological Techniques
Cytological Techniques
Cell Physiological Phenomena
Artificial Cells
11 Medical And Health Sciences
Biochemistry & Molecular Biology
Publication Status: Published
Open Access location: http://journals.sagepub.com/eprint/MZ5NPcGAz6zqSmnScXxS/full
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Faculty of Natural Sciences



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