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Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition

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Title: Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition
Authors: Caini, S
Masala, G
Saieva, C
Kvaskoff, M
Savoye, I
Sacerdote, C
Hemmingsson, O
Bech, BH
Overvad, K
Tjonneland, A
Petersen, KEN
Mancini, FR
Boutron-Ruault, M-C
Cervenka, I
Kaaks, R
Kuehn, T
Boeing, H
Floegel, A
Trichopoulou, A
Valanou, E
Kritikou, M
Tagliabue, G
Panico, S
Tumino, R
Bueno-de-Mesquita, HBA
Peeters, PH
Veierod, MB
Ghiasvand, R
Lukic, M
Ramon Quiros, J
Chirlaque, M-D
Ardanaz, E
Salamanca Fernandez, E
Larranaga, N
Zamora-Ros, R
Nilsson, LM
Ljuslinder, I
Jirstrom, K
Sonestedt, E
Key, TJ
Wareham, N
Khaw, K-T
Gunter, M
Huybrechts, I
Murphy, N
Tsilidis, KK
Weiderpass, E
Palli, D
Item Type: Journal Article
Abstract: In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a multicentre prospective study that enrolled over 500,000 participants aged 25–70 years from ten European countries in 1992–2000. Information on coffee and tea drinking was collected at baseline using validated country-specific dietary questionnaires. We used adjusted Cox proportional hazards regression models to calculate hazard ratios (HR) and 95% confidence intervals (95% CI) for the associations between coffee and tea consumption and melanoma risk. Overall, 2,712 melanoma cases were identified during a median follow-up of 14.9 years among 476,160 study participants. Consumption of caffeinated coffee was inversely associated with melanoma risk among men (HR for highest quartile of consumption vs. non-consumers 0.31, 95% CI 0.14–0.69) but not among women (HR 0.96, 95% CI 0.62–1.47). There were no statistically significant associations between consumption of decaffeinated coffee or tea and the risk of melanoma among both men and women. The consumption of caffeinated coffee was inversely associated with melanoma risk among men in this large cohort study. Further investigations are warranted to confirm our findings and clarify the possible role of caffeine and other coffee compounds in reducing the risk of melanoma.
Issue Date: 19-Mar-2017
Date of Acceptance: 1-Feb-2017
URI: http://hdl.handle.net/10044/1/48360
DOI: https://dx.doi.org/10.1002/ijc.30659
ISSN: 0020-7136
Publisher: Wiley
Start Page: 2246
End Page: 2255
Journal / Book Title: International Journal of Cancer
Volume: 140
Issue: 10
Copyright Statement: © 2017 UICC. This is the accepted version of the following article: Caini, S., Masala, G., Saieva, C., Kvaskoff, M., Savoye, I., Sacerdote, C., Hemmingsson, O., Hammer Bech, B., Overvad, K., Tjønneland, A., Petersen, K. E.N., Mancini, F. R., Boutron-Ruault, M.-C., Cervenka, I., Kaaks, R., Kühn, T., Boeing, H., Floegel, A., Trichopoulou, A., Valanou, E., Kritikou, M., Tagliabue, G., Panico, S., Tumino, R., Bueno-de-Mesquita, H. B., Peeters, P. H., Veierød, M. B., Ghiasvand, R., Lukic, M., Quirós, J. R., Chirlaque, M.-D., Ardanaz, E., Salamanca Fernández, E., Larrañaga, N., Zamora-Ros, R., Maria Nilsson, L., Ljuslinder, I., Jirström, K., Sonestedt, E., Key, T. J., Wareham, N., Khaw, K.-T., Gunter, M., Huybrechts, I., Murphy, N., Tsilidis, K. K., Weiderpass, E. and Palli, D. (2017), Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition. Int. J. Cancer, 140: 2246–2255. doi:10.1002/ijc.30659, which has been published in final form at https://dx.doi.org/10.1002/ijc.30659
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
coffee
tea
melanoma
risk
cohort study
CUTANEOUS MALIGNANT-MELANOMA
POSTMENOPAUSAL WOMEN
SOCIOECONOMIC-STATUS
PROSPECTIVE COHORT
INDUCED APOPTOSIS
CAFFEINE
INHIBITION
CELLS
METAANALYSIS
CONSUMPTION
Adult
Aged
Anticarcinogenic Agents
Coffee
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasms
Prognosis
Prospective Studies
Registries
Risk Assessment
Risk Factors
Surveys and Questionnaires
Tea
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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