Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

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Title: Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort
Authors: Duarte-Salles, T
Fedirko, V
Stepien, M
Aleksandrova, K
Bamia, C
Lagiou, P
Laursen, ASD
Hansen, L
Overvad, K
Tjonneland, A
Boutron-Ruault, M-C
Fagherazzi, G
His, M
Boeing, H
Katzke, V
Kuehn, T
Trichopoulou, A
Valanou, E
Kritikou, M
Masala, G
Panico, S
Sieri, S
Ricceri, F
Tumino, R
Bueno-de-Mesquita, HBA
Peeters, PH
Hjartaker, A
Skeie, G
Weiderpass, E
Ardanaz, E
Bonet, C
Chirlaque, M-D
Dorronsoro, M
Quiros, JR
Johansson, I
Ohlsson, B
Sjoberg, K
Wennberg, M
Khaw, K-T
Travis, RC
Wareham, N
Ferrari, P
Freisling, H
Romieu, I
Cross, AJ
Gunter, M
Lu, Y
Jenab, M
Item Type: Journal Article
Abstract: The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case–control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65–0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55–0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68–1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88–1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73–1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.
Issue Date: 15-Jun-2015
Date of Acceptance: 21-May-2015
URI: http://hdl.handle.net/10044/1/48297
DOI: https://dx.doi.org/10.1002/ijc.29643
ISSN: 0020-7136
Publisher: Wiley
Start Page: 2715
End Page: 2728
Journal / Book Title: International Journal of Cancer
Volume: 137
Issue: 11
Copyright Statement: © 2015 UICC. This is the accepted version of the following article: Duarte-Salles, T., Fedirko, V., Stepien, M., Aleksandrova, K., Bamia, C., Lagiou, P., Laursen, A. S. D., Hansen, L., Overvad, K., Tjønneland, A., Boutron-Ruault, M.-C., Fagherazzi, G., His, M., Boeing, H., Katzke, V., Kühn, T., Trichopoulou, A., Valanou, E., Kritikou, M., Masala, G., Panico, S., Sieri, S., Ricceri, F., Tumino, R., Bueno-de-Mesquita, H. B., Peeters, P. H., Hjartåker, A., Skeie, G., Weiderpass, E., Ardanaz, E., Bonet, C., Chirlaque, M.-D., Dorronsoro, M., Quirós, J. R., Johansson, I., Ohlsson, B., Sjöberg, K., Wennberg, M., Khaw, K.-T., Travis, R. C., Wareham, N., Ferrari, P., Freisling, H., Romieu, I., Cross, A. J., Gunter, M., Lu, Y. and Jenab, M. (2015), Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort. Int. J. Cancer, 137: 2715–2728, which has been published in final form at https://dx.doi.org/doi:10.1002/ijc.29643.
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
dietary fats
hepatocellular carcinoma
European populations
cohort study
RISK-FACTORS
NUTRITIONAL EPIDEMIOLOGY
MEDITERRANEAN DIET
LIVER-DISEASE
CANCER
METAANALYSIS
INDEX
ACIDS
FISH
INFLAMMATION
European populations
cohort study
dietary fats
hepatocellular carcinoma
Adult
Aged
Carcinoma, Hepatocellular
Case-Control Studies
Diet
Dietary Fats
Europe
Feeding Behavior
Female
Humans
Incidence
Life Style
Liver Neoplasms
Male
Middle Aged
Nutritional Status
Prospective Studies
Risk
Risk Factors
Surveys and Questionnaires
Young Adult
Humans
Carcinoma, Hepatocellular
Liver Neoplasms
Dietary Fats
Diet
Incidence
Risk
Risk Factors
Case-Control Studies
Prospective Studies
Food Habits
Life Style
Nutritional Status
Adult
Aged
Middle Aged
Europe
Female
Male
Young Adult
Surveys and Questionnaires
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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