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The past matters: estimating intrinsic hookworm transmission intensity in areas with past mass drug administration to control lymphatic filariasis

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Title: The past matters: estimating intrinsic hookworm transmission intensity in areas with past mass drug administration to control lymphatic filariasis
Authors: Werkman, M
Truscott, JE
Toor, J
Wright, JE
Anderson, RM
Item Type: Journal Article
Abstract: Background Current WHO guidelines for soil-transmitted helminth (STH) control focus on mass drug administration (MDA) targeting preschool-aged (pre-SAC) and school-aged children (SAC), with the goal of eliminating STH as a public health problem amongst children. Recently, attention and funding has turned towards the question whether MDA alone can result in the interruption of transmission for STH. The lymphatic filariasis (LF) elimination programme, have been successful in reaching whole communities. There is the possibility of building upon the infrastructure created for these LF-programmes to enhance the control of STH. Using hookworm as an example, we explore what further MDA coverage might be required to induce interruption of transmission for hookworm in the wake of a successful LF programme. Results Analyses based on the model of STH transmission and MDA impact predict the effects of previous LF control by MDA over five years, on a defined baseline prevalence of STH in an area with a defined transmission intensity (the basic reproductive number R0). If the LF MDA programme achieved a high coverage (70, 70 and 60% for pre-SAC, SAC and adults, respectively) we expect that in communities with a hookworm prevalence of 15%, after 5 years of LF control, the intrinsic R0 value in that setting is 2.47. By contrast, if lower LF coverages were achieved (40, 40 and 30% for pre-SAC, SAC and adults, respectively), with the same prevalence of 15% at baseline (after 5 years of LF MDA), the intrinsic hookworm R0 value is predicted to be 1.67. The intrinsic R0 value has a large effect on the expected successes of follow-up STH programmes post LF MDA. Consequently, the outcomes of identical programmes may differ between these communities. Conclusion To design the optimal MDA intervention to eliminate STH infections, it is vital to have information on historical MDA programmes and baseline prevalence to estimate the intrinsic transmission intensity for the defined setting (R0). The baseline prevalence alone is not sufficient to inform policy for the control of STH, post cessation of LF MDA, since this will be highly dependent on the intensity and effectiveness of past programmes and the intrinsic transmission intensity of the dominant STH species in any given setting.
Issue Date: 23-May-2017
Date of Acceptance: 5-May-2017
URI: http://hdl.handle.net/10044/1/48248
DOI: https://dx.doi.org/10.1186/s13071-017-2177-6
ISSN: 1756-3305
Publisher: BioMed Central
Journal / Book Title: Parasites & Vectors
Volume: 10
Copyright Statement: © The Author(s). 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Sponsor/Funder: Bill & Melinda Gates Foundation
Funder's Grant Number: SON15004
Keywords: Science & Technology
Life Sciences & Biomedicine
Parasitology
Soil-transmitted helminths
Lymphatic filariasis
Mass drug administration impact
Interrupting transmission
Transmission models
SOIL-TRANSMITTED HELMINTHS
MATHEMATICAL-MODELS
POPULATION-DYNAMICS
INFECTIONS
CHEMOTHERAPY
SCHISTOSOMES
CHILDREN
LARVAE
IMPACT
EGGS
Mycology & Parasitology
1108 Medical Microbiology
1117 Public Health And Health Services
Publication Status: Published
Open Access location: http://download.springer.com/static/pdf/790/art%253A10.1186%252Fs13071-017-2177-6.pdf?originUrl=http://parasitesandvectors.biomedcentral.com/article/10.1186/s13071-017-2177-6&token2=exp=1495779941~acl=/static/pdf/790/art%25253A10.1186%25252Fs13071-017-2177-6.pdf*~hmac=a68abd085071938d583e56ca4872424d4b223a28f921f3ae3513cfd5172925fa
Article Number: 254
Appears in Collections:Epidemiology, Public Health and Primary Care



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