Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

Title: Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy
Author(s): Pillas, D
Hoggart, CJ
Evans, DM
O'Reilly, PF
Sipila, K
Lahdesmaki, R
Millwood, IY
Kaakinen, M
Netuveli, G
Blane, D
Charoen, P
Sovio, U
Pouta, A
Freimer, N
Hartikainen, A-L
Laitinen, J
Vaara, S
Glaser, B
Crawford, P
Timpson, NJ
Ring, SM
Deng, G
Zhang, W
McCarthy, MI
Deloukas, P
Peltonen, L
Elliott, P
Coin, LJM
Smith, GD
Jarvelin, M-R
Item Type: Journal Article
Abstract: Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5×10−8, and 5 with suggestive association (P<5×10−6). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years.
Publication Date: 26-Feb-2010
Date of Acceptance: 24-Jan-2010
URI: http://hdl.handle.net/10044/1/48223
DOI: https://dx.doi.org/10.1371/journal.pgen.1000856
ISSN: 1553-7390
Publisher: Public Library of Science
Journal / Book Title: PLOS Genetics
Volume: 6
Issue: 2
Copyright Statement: © 2010 Pillas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: G0801056B
G0801056/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
GENETICS & HEREDITY
COMMON VARIANTS
BREAST-CANCER
MESSENGER-RNA
POPULATION
COHORT
GENES
TEETH
IDENTIFICATION
MICROARRAY
EXPRESSION
Alleles
England
Female
Finland
Genetic Loci
Genome-Wide Association Study
Genotype
Humans
Infant
Linkage Disequilibrium
Longitudinal Studies
Male
Meta-Analysis as Topic
Parturition
Polymorphism, Single Nucleotide
Tooth Eruption
Tooth, Deciduous
Tooth, Deciduous
Humans
Longitudinal Studies
Parturition
Tooth Eruption
Genotype
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Alleles
Infant
Finland
England
Female
Male
Meta-Analysis as Topic
Genome-Wide Association Study
Genetic Loci
Developmental Biology
0604 Genetics
Publication Status: Published
Article Number: ARTN e1000856
Appears in Collections:Department of Medicine
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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