Distinct bimodal roles of aromatic molecules in controlling gold nanorod growth for biosensing

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Title: Distinct bimodal roles of aromatic molecules in controlling gold nanorod growth for biosensing
Authors: Soh, JH
Lin, Y
Thomas, MR
Todorova, N
Kallepitis, C
Ying, JY
Yarovsky, I
Stevens, MM
Item Type: Journal Article
Abstract: New aromatic molecule–seed particle interactions are examined and exploited to control and guide seed-mediated gold nanorod (Au NR) growth. This new approach enables better understanding of how small molecules impact the synthesis of metallic nanostructures, catalysing their use in various biomedical applications, such as plasmonic biosensing. We perform experimental studies and theoretical molecular simulations using a library of aromatic molecules where we take advantage of the chemical versatility of the molecules with varied spatial arrangements of electron donating/withdrawing groups, charge, and Au-binding propensity. Au NR growth is regulated by two principal mechanisms, producing either a red or blue shift in the longitudinal localized surface plasmon resonance (LLSPR) peaks. Aromatic molecules with high redox potentials produced an increase in NR aspect ratio and red shift of LLSPR peaks. In contrast, molecules that strongly bind gold surfaces resulted in blue shifts, demonstrating a strong correlation between their binding energy and blue shifts produced. Through enzymatic conversion of selected molecules, 4-aminophenylphosphate to 4-aminophenol, we obtained opposing growth mechanisms at opposite extremes of target concentration, and established a chemical pathway for performing plasmonic ELISA. This unlocks new strategies for tailoring substrate design and enzymatic mechanisms for controlling plasmonic response to target detection in biosensing applications.
Issue Date: 26-Jun-2017
Date of Acceptance: 7-Apr-2017
URI: http://hdl.handle.net/10044/1/47946
DOI: https://dx.doi.org/10.1002/adfm.201700523
ISSN: 1616-3028
Publisher: Wiley
Journal / Book Title: Advanced Functional Materials
Volume: 27
Issue: 29
Copyright Statement: © 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/K031953/1
EP/K020641/1
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
PROSTATE-SPECIFIC ANTIGEN
REDOX POTENTIALS
MEDIATED GROWTH
COLORIMETRIC DETECTION
REFERENCE RANGES
ASCORBIC-ACID
ASPECT-RATIO
NANOPARTICLES
SURFACE
SILVER
03 Chemical Sciences
09 Engineering
02 Physical Sciences
Materials
Publication Status: Published
Open Access location: http://onlinelibrary.wiley.com/doi/10.1002/adfm.201700523/abstract
Article Number: 1700523
Appears in Collections:Faculty of Engineering
Materials
Faculty of Natural Sciences



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