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Non-random inversion landscapes in prokaryotic genomes are shaped by heterogeneous selection pressures

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Title: Non-random inversion landscapes in prokaryotic genomes are shaped by heterogeneous selection pressures
Authors: Repar, J
Warnecke, T
Item Type: Journal Article
Abstract: Inversions are a major contributor to structural genome evolution in prokaryotes. Here, using a novel alignment-based method, we systematically compare 1,651 bacterial and 98 archaeal genomes to show that inversion landscapes are frequently biased toward (symmetric) inversions around the origin–terminus axis. However, symmetric inversion bias is not a universal feature of prokaryotic genome evolution but varies considerably across clades. At the extremes, inversion landscapes in Bacillus–Clostridium and Actinobacteria are dominated by symmetric inversions, while there is little or no systematic bias favoring symmetric rearrangements in archaea with a single origin of replication. Within clades, we find strong but clade-specific relationships between symmetric inversion bias and different features of adaptive genome architecture, including the distance of essential genes to the origin of replication and the preferential localization of genes on the leading strand. We suggest that heterogeneous selection pressures have converged to produce similar patterns of structural genome evolution across prokaryotes.
Issue Date: 12-Apr-2017
Date of Acceptance: 6-Apr-2017
URI: http://hdl.handle.net/10044/1/46242
DOI: https://dx.doi.org/10.1093/molbev/msx127
ISSN: 1537-1719
Publisher: Oxford University Press (OUP)
Start Page: 1902
End Page: 1911
Journal / Book Title: Molecular Biology and Evolution
Volume: 34
Issue: 8
Copyright Statement: © The Author 2017. Published by Oxford University Press on be half of the Society for Molecular Biology and Evolution. This is an Open Access article distributed un der the terms of the Creative Commons Attrib ution License (http://creativecommons. org/licenses/by/4.0/), which permits unrest ricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Imperial College London
Medical Research Council
Funder's Grant Number: Junior Research Fellowship
MC_A658_5TY40
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Evolutionary Biology
Genetics & Heredity
inversion
replication
mutation
selection
GENE ORDER
CHROMOSOME-REPLICATION
BACTERIAL CHROMOSOME
HELICOBACTER-PYLORI
ESCHERICHIA-COLI
DNA-REPLICATION
ORIGIN
REARRANGEMENT
EVOLUTION
TRANSLOCATIONS
0604 Genetics
0603 Evolutionary Biology
0601 Biochemistry And Cell Biology
Publication Status: Published
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine



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