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Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts

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Title: Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts
Authors: Raaschou-Nielsen, O
Pedersen, M
Stafoggia, M
Weinmayr, G
Andersen, ZJ
Galassi, C
Sommar, J
Forsberg, B
Olsson, D
Oftedal, B
Krog, NH
Aasvang, GM
Pyko, A
Pershagen, G
Korek, M
De Faire, U
Pedersen, NL
OEstenson, C-G
Fratiglioni, L
Sorensen, M
Eriksen, KT
Tjonneland, A
Peeters, PH
Bueno-de-Mesquita, HBA
Plusquin, M
Key, TJ
Jaensch, A
Nagel, G
Foeger, B
Wang, M
Tsai, M-Y
Grioni, S
Marcon, A
Krogh, V
Ricceri, F
Sacerdote, C
Migliore, E
Tamayo, I
Amiano, P
Dorronsoro, M
Sokhi, R
Kooter, I
De Hoogh, K
Beelen, R
Eeftens, M
Vermeulen, R
Vineis, P
Brunekreef, B
Hoek, G
Item Type: Journal Article
Abstract: Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although not consistently. It was the aim to investigate possible associations between outdoor air pollution at the residence and the incidence of kidney parenchyma cancer in the general population. We used data from 14 European cohorts from the ESCAPE study. We geocoded and assessed air pollution concentrations at baseline addresses by land-use regression models for particulate matter (PM10, PM2.5, PMcoarse, PM2.5 absorbance (soot)) and nitrogen oxides (NO2, NOx), and collected data on traffic. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses to calculate summary hazard ratios (HRs). The 289,002 cohort members contributed 4,111,908 person-years at risk. During follow-up (mean 14.2 years) 697 incident cancers of the kidney parenchyma were diagnosed. The meta-analyses showed higher HRs in association with higher PM concentration, e.g. HR = 1.57 (95%CI: 0.81–3.01) per 5 μg/m3 PM2.5 and HR = 1.36 (95%CI: 0.84–2.19) per 10−5m−1 PM2.5 absorbance, albeit never statistically significant. The HRs in association with nitrogen oxides and traffic density on the nearest street were slightly above one. Sensitivity analyses among participants who did not change residence during follow-up showed stronger associations, but none were statistically significant. Our study provides suggestive evidence that exposure to outdoor PM at the residence may be associated with higher risk for kidney parenchyma cancer; the results should be interpreted cautiously as associations may be due to chance.
Issue Date: 6-Jan-2017
Date of Acceptance: 8-Dec-2016
URI: http://hdl.handle.net/10044/1/46219
DOI: https://dx.doi.org/10.1002/ijc.30587
ISSN: 0020-7136
Publisher: WILEY
Start Page: 1528
End Page: 1537
Journal / Book Title: INTERNATIONAL JOURNAL OF CANCER
Volume: 140
Issue: 7
Copyright Statement: © 2016 UICC. This is the accepted version of the following article: Raaschou-Nielsen, O., Pedersen, M., Stafoggia, M., Weinmayr, G., Andersen, Z. J., Galassi, C., Sommar, J., Forsberg, B., Olsson, D., Oftedal, B., Krog, N. H., Aasvang, G. M., Pyko, A., Pershagen, G., Korek, M., De Faire, U., Pedersen, N. L., Östenson, C.-G., Fratiglioni, L., Sørensen, M., Eriksen, K. T., Tjønneland, A., Peeters, P. H., Bueno-de-Mesquita, H. B., Plusquin, M., Key, T. J., Jaensch, A., Nagel, G., Föger, B., Wang, M., Tsai, M.-Y., Grioni, S., Marcon, A., Krogh, V., Ricceri, F., Sacerdote, C., Migliore, E., Tamayo, I., Amiano, P., Dorronsoro, M., Sokhi, R., Kooter, I., de Hoogh, K., Beelen, R., Eeftens, M., Vermeulen, R., Vineis, P., Brunekreef, B. and Hoek, G. (2017), Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts. Int. J. Cancer, 140: 1528–1537. doi:10.1002/ijc.30587, which has been published in final form at: https://dx.doi.org/10.1002/ijc.30587
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 211250
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
USE REGRESSION-MODELS
INHALED ULTRAFINE PARTICLES
RENAL-CELL CARCINOMA
PARTICULATE MATTER
ESCAPE PROJECT
PM2.5 ABSORBENCY
LUNG-CANCER
NO2
MORTALITY
EXPOSURE
Adult
Air Pollutants
Air Pollution
Cohort Studies
Environmental Exposure
Europe
Female
Gasoline
Humans
Kidney Neoplasms
Lung Neoplasms
Male
Middle Aged
Particle Size
Particulate Matter
Risk Factors
Vehicle Emissions
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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