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Pancreatic β-cell imaging in humans: fiction or option?

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Title: Pancreatic β-cell imaging in humans: fiction or option?
Authors: Laurent, D
Vinet, L
Lamprianou, S
Daval, M
Filhoulaud, G
Ktorza, A
Wang, H
Sewing, S
Juretschke, H-P
Glombik, H
Meda, P
Boisgard, R
Nguyen, DL
Stasiuk, GJ
Long, NJ
Montet, X
Hecht, P
Kramer, W
Rutter, GA
Hecksher-Sorensen, J
Item Type: Journal Article
Abstract: Diabetes mellitus is a growing worldwide epidemic disease, currently affecting 1 in 12 adults. Treatment of disease complications typically consumes ∼10% of healthcare budgets in developed societies. Whilst immune-mediated destruction of insulin-secreting pancreatic β cells is responsible for Type 1 diabetes, both the loss and dysfunction of these cells underly the more prevalent Type 2 diabetes. The establishment of robust drug development programmes aimed at β-cell restoration is still hampered by the absence of means to measure β-cell mass prospectively in vivo, an approach which would provide new opportunities for understanding disease mechanisms and ultimately assigning personalized treatments. In the present review, we describe the progress towards this goal achieved by the Innovative Medicines Initiative in Diabetes, a collaborative public–private consortium supported by the European Commission and by dedicated resources of pharmaceutical companies. We compare several of the available imaging methods and molecular targets and provide suggestions as to the likeliest to lead to tractable approaches. Furthermore, we discuss the simultaneous development of animal models that can be used to measure subtle changes in β-cell mass, a prerequisite for validating the clinical potential of the different imaging tracers.
Issue Date: 5-Oct-2015
Date of Acceptance: 28-Jul-2015
URI: http://hdl.handle.net/10044/1/46218
DOI: https://dx.doi.org/10.1111/dom.12544
ISSN: 1462-8902
Publisher: Wiley
Start Page: 6
End Page: 15
Journal / Book Title: Diabetes Obesity & Metabolism
Volume: 18
Issue: 1
Copyright Statement: © 2015 John Wiley & Sons Ltd. "This is the peer reviewed version of the following article:Laurent, D., Vinet, L., Lamprianou, S., Daval, M., Filhoulaud, G., Ktorza, A., Wang, H., Sewing, S., Juretschke, H.-P., Glombik, H., Meda, P., Boisgard, R., Nguyen, D. L., Stasiuk, G. J., Long, N. J., Montet, X., Hecht, P., Kramer, W., Rutter, G. A. and Hecksher-Sørensen, J. (2016), Pancreatic β-cell imaging in humans: fiction or option?. Diabetes Obes Metab, 18: 6–15. doi:10.1111/dom.12544, which has been published in final form at https://dx.doi.org/10.1111/dom.12544. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving https://authorservices.wiley.com/author-resources/Journal-Authors/licensing-open-access/open-access/self-archiving.html ."
Sponsor/Funder: The Royal Society
Wellcome Trust
Medical Research Council (MRC)
Wellcome Trust
Wellcome Trust
Medical Research Council (MRC)
Funder's Grant Number: WM100078
097816/Z/11/ZR
MR/K001981/1
097816/Z/11/A
098424/Z/12/ZR
R26199/CN001
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
beta cell
GLP-1 analogue
islets
sulphonylureas
type 1 diabetes
VMAT2
POSITRON-EMISSION-TOMOGRAPHY
TRANSGENIC MOUSE MODEL
IN-VIVO
PEPTIDE-1 RECEPTOR
ENDOCRINE PANCREAS
ADHESION MOLECULE
DIABETES-MELLITUS
EXOCRINE PANCREAS
RAT PANCREAS
PSA-NCAM
Adult
Animals
Cell Adhesion
Diabetes Mellitus
Glucagon-Like Peptide-1 Receptor
Humans
Insulin-Secreting Cells
Luminescent Measurements
Manganese
Membrane Glycoproteins
Mice
Molecular Imaging
Rats
Sulfonylurea Receptors
Vesicular Monoamine Transport Proteins
Zinc
1103 Clinical Sciences
Publication Status: Published
Appears in Collections:Chemistry
Catalysis and Advanced Materials
Department of Medicine
Faculty of Medicine
Faculty of Natural Sciences



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